Clinical data | |
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Trade names | Tykerb, Tyverb, others |
Other names | Lapatinib ditosylate |
AHFS/Drugs.com | Monograph |
MedlinePlus | a607055 |
License data | |
Pregnancy category |
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Routes of administration | By mouth (tablets) |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | Variable, increased with food |
Protein binding | >99% |
Metabolism | Liver, mostly CYP3A-mediated (minor 2C19 and 2C8 involvement) |
Elimination half-life | 24 hours (repeated dosing), 14.2 hours (single dose) |
Excretion | Mostly Feces |
Identifiers | |
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Chemical and physical data | |
Formula | C29H26ClFN4O4S |
Molar mass | 581.06 g·mol−1 |
3D model (JSmol) | |
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Lapatinib, sold under the brand names Tykerb and Tyverb is a medication used to treat breast cancer.[1] Specifically it is used for HER2 positive breast cancer with either letrozole, trastuzumab, or capecitabine.[1][2] It is taken by mouth.[1]
Common side effects include diarrhea, nausea, rash, tiredness, liver problems, itchiness, and hair loss.[1] Other side effects may include QT prolongation, pneumonitis, low platelets, low red blood cells, or low white blood cells.[1] Use in pregnancy may harm the baby.[1] It is a tyrosine kinase inhibitor which blocks HER2/neu and epidermal growth factor receptor (EGFR).[3]
Lapatinib was approved for medical use in the United States in 2007 and Europe in 2008.[1][2] In the United Kingdom 4 weeks of 1,000 mg costs the NHS about £970 as of 2021.[4] This amount in the United States costs about 4,300 USD.[5]
References
edit- ^ a b c d e f g "Lapatinib Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 20 November 2021.
- ^ a b "Tyverb". Archived from the original on 23 October 2021. Retrieved 20 November 2021.
- ^ Higa GM, Abraham J (September 2007). "Lapatinib in the treatment of breast cancer". Expert Review of Anticancer Therapy. 7 (9): 1183–92. doi:10.1586/14737140.7.9.1183. PMID 17892419. S2CID 36837880. Archived from the original on 2021-05-25. Retrieved 2021-10-03.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1031. ISBN 978-0857114105.
- ^ "Lapatinib Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 20 November 2021.