 | |
| Clinical data | |
|---|---|
| Pronunciation | /ləˈbɛtəlɔːl/ |
| Trade names | Normodyne, Trandate, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a685034 |
| License data | |
| Pregnancy category |
|
| Routes of administration | By mouth, intravenous |
| Drug class | Beta blocker[1] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 25% |
| Protein binding | 50% |
| Metabolism | Liver pass metabolism, |
| Onset of action | Within 10 min (iv)[2] |
| Elimination half-life | Tablet: 6-8 hours; IV: 5.5 hours |
| Duration of action | Up to 6 hrs (iv)[2] |
| Excretion | Excreted in urine, not removed by hemodialysis |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C19H24N2O3 |
| Molar mass | 328.412 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
| (verify) | |
Labetalol is a medication used to treat high blood pressure and in long term management of angina.[1][5] This includes essential hypertension, hypertensive emergencies, and hypertension of pregnancy.[5] In essential hypertension it is generally less preferred than a number of other blood pressure medications.[1] It can be given by mouth or by injection into a vein.[1]
Common side effects include low blood pressure with standing, dizziness, feeling tired, and nausea.[1] Serious side effects may include low blood pressure, liver problems, heart failure, and bronchospasm.[1] Use appears safe in the latter part of pregnancy and it is not expected to cause problems during breastfeeding.[5][6] It works by blocking the activation of both α-receptors and β-receptors.[7]
Labetalol was patented in 1966 and came into medical use in 1977.[8] It is available as a generic medication.[5] A month supply of labetalol at 200mg three times daily, in the United Kingdom, costs the NHS less than £15 as of 2020.[5] In the United States the same dose for a month costs just less than US$24.[9] In 2017, it was the 211th most commonly prescribed medication in the United States, with more than two million prescriptions.[10][11]
References
edit- ^ a b c d e f g "Labetalol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 15 February 2021. Retrieved 15 February 2021.
- ^ a b Cite error: The named reference
EMCrit2024was invoked but never defined (see the help page). - ^ Cite error: The named reference
MSF2020was invoked but never defined (see the help page). - ^ Cite error: The named reference
WHO2020DDDwas invoked but never defined (see the help page). - ^ a b c d e BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 160-161. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ "Labetalol Use During Pregnancy". Drugs.com. Archived from the original on 29 November 2020. Retrieved 11 March 2019.
- ^ Ritter, Professor of Clinical Pharmacology Guy's King's and St Thomas's Medical Schools James M.; Flower, Rod J.; Henderson, Graeme; Loke, Yoon Kong; MacEwan, David; Rang, Humphrey P. (2020). "15. Noradrenergic transmission". Rang & Dale's Pharmacology. Elsevier. p. 210. ISBN 978-0-7020-7448-6. Archived from the original on 2021-08-28. Retrieved 2021-03-01.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 463. ISBN 9783527607495. Archived from the original on 2018-12-24. Retrieved 2019-03-01.
- ^ "Labetalol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 15 February 2021. Retrieved 15 February 2021.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Labetalol - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.