 | |
| Clinical data | |
|---|---|
| Trade names | Isoprenaline Macure, others[1] |
| Other names | Isoproterenol (USAN US) |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a601236 |
| Pregnancy category |
|
| Routes of administration | Inhalation (80–120 μg), intravenous injection (IV) |
| Drug class | β adrenoceptor agonist (non-selective)[2] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Elimination half-life | ~2 minutes |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C11H17NO3 |
| Molar mass | 211.261 g·mol−1 |
| 3D model (JSmol) | |
| |
| |
| (verify) | |
Isoprenaline, also known as isoproterenol, is a medication which has been used to treat slow heart rate, heart block, shock, and bronchospasm.[3] In shock, norepinephrine is generally preferred.[3] It is generally given by injection.[3]
Common side effects include headache, anxiety, blurry vision, palpitations, chest pain, sweating, and tremor.[3] It should not be used in people with cardiac glycoside toxicity.[3] Use in pregnancy appears safe.[4] It is a non-selective β adrenoceptor agonist.[2]
Isoprenaline was approved for medical use in the US in 1947.[5] In the United States 0.2 mg for injection costs about 190 USD as of 2021.[6] By mouth and inhaled forms are no longer available commercially in the United States.[3] It is available under various brand names.[1]
References edit
- ^ a b "Isoprenaline international brands". Drugs.com. Archived from the original on 26 June 2019. Retrieved 21 June 2017.
- ^ a b "Label: Isoproterenol hydrochloride injection, solution". NIH DailyMed. September 10, 2013. Archived from the original on 11 January 2017. Retrieved 21 June 2017.
- ^ a b c d e f g h "Isoproterenol Monograph for Professionals". Drugs.com. Archived from the original on 28 January 2021. Retrieved 28 November 2021.
- ^ "Isoproterenol Use During Pregnancy". Drugs.com. Archived from the original on 28 November 2020. Retrieved 28 November 2021.
- ^ Mozayani, Ashraf; Raymon, Lionel (2003). Handbook of Drug Interactions: A Clinical and Forensic Guide. Springer Science & Business Media. pp. 541–542. ISBN 9781592596546. Archived from the original on 2019-12-15. Retrieved 2021-10-18.
- ^ "Isoproterenol Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 27 January 2021. Retrieved 28 November 2021.