Clinical data | |
---|---|
Trade names | Monopril |
Other names | Fosinopril sodium |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692020 |
Pregnancy category |
|
Routes of administration | By mouth |
Drug class | ACE inhibitor[1] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | ~36% |
Protein binding | 87% (fosinoprilat) |
Metabolism | Liver, GIT mucosa (to fosinoprilat) |
Elimination half-life | 12 hours (fosinoprilat) |
Excretion | Kidney |
Identifiers | |
| |
Chemical and physical data | |
Formula | C30H46NO7P |
Molar mass | 563.672 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
Fosinopril, sold under the brand name Monopril among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[2][1] It is one of a number of first line agents for high blood pressure.[1] It is taken by mouth.[2]
Common side effects include cough, nausea, and dizziness.[1] Other side effects may include low blood pressure, liver problems, allergic reactions, high potassium, and kidney problems.[1] Use during pregnancy may harm the baby.[1] It is a angiotensin converting enzyme (ACE) inhibitor.[1]
Fosinopril was patented in 1980 and approved for medical use in 1991.[3] It is available as a generic medication.[2] In the United Kingdom 4 weeks of 20 mg cost the NHS about £2 as of 2021.[2] This amount in the United States costs about 10 USD.[4]
References
edit- ^ a b c d e f g h "Fosinopril Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 13 December 2021.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 183. ISBN 978-0857114105.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495. Archived from the original on 2020-10-18. Retrieved 2021-10-15.
- ^ "Fosinopril Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 13 December 2021.