Clinical data | |
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Trade names | Flovent, Flixotide, Flonase, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a695002 |
License data |
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Pregnancy category |
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Routes of administration | Intranasal,[2] inhaled,[3] topical[4] |
Drug class | Steroids and steroid derivatives |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 0.51% (intranasal) |
Protein binding | 91% |
Metabolism | Intranasal Liver (CYP3A4-mediated) |
Elimination half-life | 10 hours |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C25H31F3O5S |
Molar mass | 500.57 g·mol−1 |
3D model (JSmol) | |
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Fluticasone propionate, sold under the brand names Flovent and Flonase among others, is a steroid medication.[8] When inhaled it is used for the long term management of asthma and COPD.[8] In the nose it is used for hay fever and nasal polyps.[9][10] It can also be used for mouth ulcers.[11]
Common side effects when inhaled include upper respiratory tract infections, sinusitis, thrush, and cough.[8] Common side effects when used in the nose include nosebleeding and sore throat.[9] It works by decreasing inflammation.[8]
Fluticasone propionate was patented in 1980, and approved for medical use in 1990.[12] It is available as a generic medication.[10] In the United States the wholesale cost per spray is about 0.33 USD as of 2018.[13] In the United Kingdom, it costs the NHS about 0.13 GBP per spray as of 2019.[10] In 2018, it was the sixteenth most commonly prescribed medication in the United States, with more than 34 million prescriptions.[14][15]
References
edit- ^ a b "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 31 January 2020.
- ^ "Flonase Allergy Relief- fluticasone propionate spray, metered". DailyMed. 30 May 2019. Archived from the original on 2 December 2020. Retrieved 31 January 2020.
- ^ "Flovent Diskus- fluticasone propionate powder, metered". DailyMed. 7 January 2019. Archived from the original on 7 December 2019. Retrieved 31 January 2020.
- ^ "Cutivate- fluticasone propionate ointment". DailyMed. 18 February 2019. Archived from the original on 28 August 2021. Retrieved 31 January 2020.
- ^ "Flixonase Aqueous Nasal Spray - Summary of Product Characteristics (SmPC)". (emc). 25 October 2019. Archived from the original on 31 January 2020. Retrieved 31 January 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 19 August 2020. Retrieved 9 September 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 20 August 2020. Retrieved 9 September 2020.
- ^ a b c d "Fluticasone Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
- ^ a b "Fluticasone Propionate eent Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 February 2019. Retrieved 27 February 2019.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 262, 1172. ISBN 9780857113382.
- ^ "Flixonase aqueous spray" (PDF). Sheffield Teaching Hospitals. June 2018. Archived (PDF) from the original on 25 September 2019. Retrieved 31 January 2020.
- ^ Fischer, János; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 28 February 2019. Retrieved 28 February 2019.
- ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Archived from the original on 19 December 2018. Retrieved 22 December 2018.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 12 February 2021. Retrieved 18 February 2021.
- ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 18 February 2021.