Clinical data | |
---|---|
Trade names | Toviaz, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609021 |
License data |
|
Routes of administration | By mouth |
Drug class | Antimuscarinic[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 52% (active metabolite) |
Protein binding | 50% (active metabolite) |
Metabolism | Liver (CYP2D6- and 3A4-mediated) |
Elimination half-life | 7–8 hours (active metabolite) |
Excretion | Kidney (70%) and fecal (7%) |
Identifiers | |
| |
Chemical and physical data | |
Formula | C26H37NO3 |
Molar mass | 411.586 g·mol−1 |
3D model (JSmol) | |
| |
| |
(what is this?) (verify) |
Fesoterodine, sold under the brand name Toviaz among others, is a medication used to treat the symptoms of overactive bladder syndrome (OAB).[1][3] It is a second line medication for this use.[4] It is taken by mouth.[1]
Common side effects include dry mouth and constipation.[1] Other side effects may include urinary retention, trouble sleeping, and dizziness.[1][4] It is not recommended in people with severe liver problems or myasthenia gravis.[3] It is an antimuscarinic and works via the same chemical as tolterodine.[1]
Fesoterodine was approved for medical use in Europe in 2007,[3] the United States in 2008,[1] and Canada in 2012.[5] In the United States it costs about 310 USD per month as of 2021.[6] This amount in the United Kingdom costs the NHS about £26.[4]
References
edit- ^ a b c d e f g h i j "Fesoterodine Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 23 July 2021.
- ^ "Fesoterodine (Toviaz) Use During Pregnancy". Drugs.com. 7 November 2019. Archived from the original on 29 November 2020. Retrieved 12 August 2020.
- ^ a b c "Toviaz". Archived from the original on 12 November 2020. Retrieved 4 August 2021.
- ^ a b c BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 821. ISBN 978-0-85711-369-6.
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: CS1 maint: date format (link) - ^ "Notice of Decision for TOVIAZ". Archived from the original on 2012-04-23. Retrieved 2012-04-20.
- ^ "Toviaz Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 4 August 2021.