 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Etizest, Etilaam, Etizex, Depas, Sedekopan, Pasaden, others |
| Other names | Etiz, etizzy[1] |
| Dependence liability | Moderate[1] |
| Routes of administration | By mouth, under the tongue, rectal |
| Drug class | Thienodiazepine |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 93% |
| Metabolism | Liver |
| Elimination half-life | 3.4 hours[5][6] (main metabolite is 8.2 hours)[7] |
| Duration of action | 5-7 hours |
| Excretion | Kidney |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C17H15ClN4S |
| Molar mass | 342.85 g·mol−1 |
  (what is this?) (verify) | |
Etizolam, sold the brand name Depas among others, is medication used for general anxiety disorder, panic disorder, and insomnia.[1][8] It may be used short term but does not appear to be better than benzodiazepines.[9] It is taken by mouth.[1]
Side effects may include sleepiness, muscle weakness, poor coordination, fainting, headache, confusion, slurred speech, and sexual dysfunction.[8] There is also a risk of abuse and dependence.[8] It is a thienodiazepine, which are similar to benzodiazepines.[8] It actions via the benzodiazepine site of the GABAA receptors.[1] It possesses anxiolytic, anticonvulsant, sedative, hypnotic, and skeletal muscle relaxant effects.[8]
Etizolam was patented in 1971 and approved for medical use in 1984.[10][8] As of 2020 it was approved for medical use in Japan, Italy, and India but not in the United States.[1][8] There has been concerns regarding increasing misuse in Europe and the United States.[1] It is also known by a number of street names including Etiz and Etizzy.[1]
References edit
- ^ a b c d e f g h i "Etizolam (INN)" (PDF). WHO. November 2015. Archived (PDF) from the original on 11 July 2021. Retrieved 15 August 2021.
- ^ "Controlled Substance Schedule | SCDHEC". www.scdhec.gov. Archived from the original on 2019-03-30. Retrieved 2019-03-20.
- ^ "Arizona HB2033 | 2017 | Fifty-third Legislature 1st Regular". LegiScan. Archived from the original on 2020-11-17. Retrieved 2021-08-04.
- ^ "Ellington's bill banning two deadly drugs could soon be law - State of Indiana House of Representatives". www.indianahouserepublicans.com. Archived from the original on 2020-11-17. Retrieved 2021-08-04.
- ^ "Etizolam". www.drugbank.ca. Archived from the original on 2020-03-06. Retrieved 2020-09-03.
- ^ U.S. Drug Enforcement Administration (March 2020). "Drug & Chemical Evaluation - Etizolam" (PDF). U.S. Department of Justice. Archived (PDF) from the original on September 2020.
{{cite web}}: Check date values in:|archive-date=(help) - ^ Fracasso, C.; Confalonieri, S.; Garattini, S.; Caccia, S. (1991-02-01). "Single and multiple dose pharmacokinetics of etizolam in healthy subjects". European Journal of Clinical Pharmacology. 40 (2): 181–185. doi:10.1007/BF00280074 (inactive 31 May 2021). ISSN 1432-1041. PMID 2065698. Archived from the original on 2017-05-19. Retrieved 2021-08-04.
{{cite journal}}: CS1 maint: DOI inactive as of May 2021 (link) - ^ a b c d e f g h i "Etizolam" (PDF). Drug Enforcement Administration. March 2020. Archived (PDF) from the original on 3 September 2020. Retrieved 16 August 2021.
- ^ Tripathi, K. D. (31 October 2018). Essentials of Medical Pharmacology. Jaypee Brothers Medical Publishers. p. 433. ISBN 978-93-5270-499-6. Archived from the original on 28 August 2021. Retrieved 16 August 2021.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 536. ISBN 9783527607495. Archived from the original on 2021-08-28. Retrieved 2021-08-04.