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Trade names | Harmogen, Improvera, Ogen, Ortho-Est, Sulestrex, others |
Other names | Piperazine estrone sulfate;[1] Estrone sulfate piperazine salt; Pipestrone |
AHFS/Drugs.com | Monograph |
Routes of administration | By mouth |
Drug class | Estrogen |
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Chemical and physical data | |
Formula | C22H32N2O5S |
Molar mass | 436.57 g·mol−1 |
3D model (JSmol) | |
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Estropipate, sold under the brand name Ogen among others, is a medication used to treat the symptoms of menopause and ovarian failure.[1] It was previously also used to prevent postmenopausal osteoporosis.[1] It is taken by mouth.[1]
Common side effects include headache, breast pain, irregular vaginal bleeding, abdominal cramps, and nausea.[1] Other side effects may include high blood pressure, liver problems, high sugar, swelling, hair loss, and vaginal yeast infections.[1] Rarely blood clots or gallbladder disease may occur.[1] It is an estrogen, specifically a salt of estrone sulfate and piperazine, which is transformed into estrone and estradiol in the body.[2][3]
Estropipate was first made commercially in the United States in 1950.[4] In the United States 100 tablets of 0.75 mg used to cost about 50 USD.[5] Production; however, has been discontinued in the United States as of 2021.[6][7]
References
edit- ^ a b c d e f g h i "DailyMed - ESTROPIPATE tablet". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 17 December 2021.
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 900–. ISBN 978-1-4757-2085-3. Archived from the original on 27 June 2021. Retrieved 19 October 2020.
- ^ Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 114–. ISBN 978-94-011-4439-1.
- ^ Report on Carcinogens: Carcinogen Profiles. Department of Health and Human Services, Public Health Service, National Toxicology Program. 2000. p. RA1-PA26. Archived from the original on 2022-01-11. Retrieved 2021-12-17.
- ^ "Estropipate Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 17 December 2021.
- ^ "Estropipate Prices and Estropipate Coupons - GoodRx". GoodRx. Retrieved 17 December 2021.
- ^ "Drugs@FDA: FDA-Approved Drugs". www.accessdata.fda.gov. Archived from the original on 22 March 2021. Retrieved 19 December 2021.