Clinical data | |
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Trade names | Declomycin |
Other names | Demeclocycline hydrochloride, RP-10192 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682103 |
Routes of administration | By mouth |
Drug class | Tetracycline antibiotic[1] |
Legal status | |
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Pharmacokinetic data | |
Bioavailability | 60–80% |
Protein binding | 41–50% |
Metabolism | Liver |
Elimination half-life | 10–17 hours |
Excretion | Kidney |
Identifiers | |
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Chemical and physical data | |
Formula | C21H21ClN2O8 |
Molar mass | 464.86 g·mol−1 |
3D model (JSmol) | |
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Demeclocycline, sold under the brand names Declomycin among others, is a tetracycline antibiotic used to treat a number of bacterial infections as well as low sodium due to syndrome of inappropriate ADH (SIADH).[2] These infections include pneumonia, acne, chlamydia, gonorrhea, and syphilis.[1] It is taken by my mouth.[2]
Common side effects include nausea, rash, kidney problems, and allergic reactions.[1] Other side effects may include diabetes insipidus and a feeling of the world spinning.[1] Use in pregnancy may harm the baby and use in children under 8 not generally recommended.[1] Other side effects may include sunburns.[2]
Demeclocycline has been approved for medical use in the United States since at least 1960.[1] It is available as a generic medication.[2] In the United Kingdom 28 tablets of 150 mg costs the NHS about £220 as of 2021.[2] In the United States this amount is about 70 USD.[3] It is made from Streptomyces aureofaciens.[1]
References
edit- ^ a b c d e f g h "Demeclocycline Monograph for Professionals". Drugs.com. Archived from the original on 23 January 2021. Retrieved 23 December 2021.
- ^ a b c d e f BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 601. ISBN 978-0857114105.
- ^ "Demeclocycline Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 23 December 2021.