Clinical data | |
---|---|
Trade names | Firmagon, others |
Other names | FE-200486 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a609022 |
License data | |
Pregnancy category | |
Routes of administration | Subcutaneous injection |
Drug class | GnRH analogue; GnRH antagonist; Antigonadotropin |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 30–40% |
Protein binding | ~90% |
Metabolism | Subject to common peptidic degradation during passage through the hepato-biliary system; not a substrate for the human CYP450 system |
Elimination half-life | 23–61 days |
Excretion | Feces: 70–80% Urine: 20–30% |
Chemical and physical data | |
Formula | C82H103ClN18O16 |
Molar mass | 1632.29 g·mol−1 |
3D model (JSmol) | |
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Degarelix, sold under the brand name Firmagon among others, is a medication used to treat prostate cancer.[3][4] Specifically it is used for advanced disease that is hormone dependent.[5] It is given by injection under the skin.[5]
Common side effects include pain at the site of injection, hot flushes, and liver problems.[3] Other side effects may include anaphylaxis, QT prolongation, and infertility.[3] Use in pregnancy may harm the baby.[3] It is a GnRH receptor antagonist and works by reducing the amount of testosterone in the body.[3][6]
Degarelix was approved for medical use in the United States in 2008 and Europe in 2009.[4][6] In the United Kingdom 80 mg cost the NHS about £130 as of 2021.[5] In the United States this amount costs about 520 USD.[7]
References
edit- ^ a b c "Degarelix (Firmagon) Use During Pregnancy". Drugs.com. 3 February 2020. Archived from the original on 26 February 2020. Retrieved 25 February 2020.
- ^ "Firmagon 120mg Injection - Summary of Product Characteristics (SmPC)". (emc). 15 January 2020. Archived from the original on 26 February 2020. Retrieved 25 February 2020.
- ^ a b c d e f g "Firmagon- degarelix kit". DailyMed. 18 September 2019. Archived from the original on 12 August 2020. Retrieved 26 February 2020.
- ^ a b "Degarelix Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 22 December 2021.
- ^ a b c BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 992. ISBN 978-0857114105.
- ^ a b "Firmagon". Archived from the original on 26 February 2020. Retrieved 22 December 2021.
- ^ "Firmagon Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 22 December 2021.