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User:Mr. Ibrahem/Cromoglicic acid

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Mr. Ibrahem/Cromoglicic acid
Clinical data
Trade namesCrolom, Nasalcrom, others
Other namesCromolyn, cromolyn sodium, cromoglycate, cromoglicate
AHFS/Drugs.comInahled: Monograph
Eye&nose: Monograph
License data
Pregnancy
category
  • AU: B1
Routes of
administration		Nasal spray, inhaled, eye drop
Drug classMast cell stabilizer[1]
Legal status
Legal status
  • AU: S2 (Pharmacy medicine)
  • UK: Inhaler POM; eye OTC
  • US: OTC Nasal; eye, inhaler: Rx only
Pharmacokinetic data
Bioavailability1%
Elimination half-life1.3 hours
Identifiers
  • 5,5′-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4H-chromene-2-carboxylic acid)
Chemical and physical data
FormulaC23H16O11
Molar mass468.370 g·mol−1
3D model (JSmol)
  • O=C(O)C=4Oc3cccc(OCC(O)COc2cccc1O/C(=C\C(=O)c12)C(=O)O)c3C(=O)C=4
  • InChI=1S/C23H16O11/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30) checkY
  • Key:IMZMKUWMOSJXDT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Cromoglicic acid, also known as cromolyn, is a medication used to treat asthma, allergic rhinitis, allergic conjunctivitis, and systemic mastocytosis.[1][2] In asthma it is not a preferred treatment.[1] It is inhaled, or used as a nasal spray or eye drop[1][2]

Common side effects when inhaled include stuffy nose, cough, and nausea.[1] Common side effects when placed in the nose or eyes include burning or irritation.[2] Other side effects may include anaphylaxis.[1] While there is no evidence of harm in pregnancy, such use has not been well studied.[3] It is a mast cell stabilizer, which decreases the release of histamine.[1][4]

Cromoglicic acid was made in 1965 and came into medical use in the United States in 1973.[4] It is available as a generic medication.[5] In the United States 120 containers of 5 ml to inhale costs about 130 USD; while 10 ml of eye drops costs about 9 USD as of 2022.[6][5]

References edit

  1. ^ a b c d e f g h i "Cromolyn (Systemic, Oral Inhalation) Monograph for Professionals". Drugs.com. Archived from the original on 18 January 2021. Retrieved 7 January 2022.
  2. ^ a b c d e "Cromolyn (EENT) Monograph for Professionals". Drugs.com. Archived from the original on 26 January 2021. Retrieved 7 January 2022.
  3. ^ "Cromolyn Use During Pregnancy". Drugs.com. Archived from the original on 25 November 2020. Retrieved 7 January 2022.
  4. ^ a b Ebadi, Manuchair (31 October 2007). Desk Reference of Clinical Pharmacology. CRC Press. p. 485. ISBN 978-1-4200-4744-8. Archived from the original on 11 January 2022. Retrieved 7 January 2022.
  5. ^ a b "Cromolyn Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 7 January 2022.
  6. ^ "Cromolyn Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 7 January 2022.
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