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User:Mr. Ibrahem/Clobetasol propionate

< User:Mr. Ibrahem
Not to be confused with Clostebol propionate.
Mr. Ibrahem/Clobetasol propionate
Clinical data
Pronunciation/kloʊˈbeɪtəsɒl/[1]
Trade namesTemovate, Clobex, others
AHFS/Drugs.comMonograph
License data
Routes of
administration		Topical only
Drug classCorticosteroid[2]
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • [17-(2'-Chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
Chemical and physical data
FormulaC25H32ClFO5
Molar mass466.97 g·mol−1
3D model (JSmol)
  • ClCC(=O)[C@]3(OC(=O)CC)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)CC[C@H]4[C@@H]2C[C@@H]3C)C)C
  • InChI=1S/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/m0/s1 checkY
  • Key:CBGUOGMQLZIXBE-XGQKBEPLSA-N checkY
  (verify)

Clobetasol propionate is a corticosteroid used to treat skin conditions such as eczema, contact dermatitis, seborrheic dermatitis, and psoriasis.[2] It is applied to the skin as a cream, ointment, or shampoo.[2][4] Use should be short term and only if other weaker corticosteroids are not effective.[4] Use is not recommended in rosacea or perioral dermatitis.[2]

Common side effects include skin irritation, dry skin, redness, pimples, and telangiectasia.[2] Serious side effects may include adrenal suppression, allergic reactions, cellulitis, and Cushing's syndrome.[2] Use in pregnancy and breastfeeding is of unclear safety.[5] Clobetasol is believed to work by activating steroid receptors.[2] It is a US class I (Europe: class IV) corticosteroid, making it one of the strongest available.[6]

Clobetasol propionate was patented in 1968 and came into medical use in 1978.[7] It is available as a generic medication.[4] A month supply in the United Kingdom costs the NHS about 7.90 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$66.[8] In 2017, it was the 209th most commonly prescribed medication in the United States, with more than two million prescriptions.[9][10]

References

edit
  1. ^ "Clobetasol Propionate Topical Ointment 0.05% Information – Drug Encyclopedia". Kaiser Permanente. Archived from the original on 2021-08-28. Retrieved 2009-10-09.
  2. ^ a b c d e f g h i "Clobetasol Propionate Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  3. ^ Cite error: The named reference who was invoked but never defined (see the help page).
  4. ^ a b c d British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 1210. ISBN 9780857113382.
  5. ^ "Clobetasol topical Use During Pregnancy". Drugs.com. Archived from the original on 28 August 2021. Retrieved 13 April 2019.
  6. ^ Ference, JD; Last, AR (15 January 2009). "Choosing topical corticosteroids". American family physician. 79 (2): 135–40. PMID 19178066.
  7. ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 487. ISBN 9783527607495. Archived from the original on 2019-02-28. Retrieved 2019-03-01.
  8. ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
  9. ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
  10. ^ "Clobetasol Propionate - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.
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