 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Coreg, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a697042 |
| License data |
|
| Pregnancy category |
|
| Routes of administration | By mouth |
| Drug class | Nonselective beta blocker[1] |
| Legal status | |
| Legal status |
|
| Pharmacokinetic data | |
| Bioavailability | 25–35% |
| Protein binding | 98% |
| Metabolism | Liver (CYP2D6, CYP2C9) |
| Elimination half-life | 7–10 hours |
| Excretion | Urine (16%), Feces (60%) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C24H26N2O4 |
| Molar mass | 406.474 g·mol−1 |
| 3D model (JSmol) | |
| Chirality | Racemic mixture |
| |
| |
| (verify) | |
Carvedilol, sold under the brand name Coreg among others, is a medication used to treat high blood pressure, congestive heart failure (CHF), and left ventricular dysfunction in people who are otherwise stable.[1] For high blood pressure, it is generally a second-line treatment.[1] It is taken by mouth.[1]
Common side effects include dizziness, tiredness, joint pain, low blood pressure, nausea, and shortness of breath.[1] Severe side effects may include bronchospasm.[1] Safety during pregnancy or breastfeeding is unclear.[3] Use is not recommended with liver problems.[4] Carvedilol is a nonselective beta blocker and alpha-1 blocker.[1] How it improves outcomes is not entirely clear but may involve dilation of blood vessels.[1]
Carvedilol was patented in 1978 and approved for medical use in the United States in 1995.[1][5] It is available as a generic medication.[1] In the United States, the wholesale cost per dose is less than 0.05 USD as of 2018.[6] In 2017, it was the 29th most commonly prescribed medication in the United States, with more than 22 million prescriptions.[7][8]
References edit
- ^ a b c d e f g h i j k l "Carvedilol Monograph for Professionals". Drugs.com. AHFS. Retrieved 24 December 2018.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 9 September 2020.
- ^ "Carvedilol Use During Pregnancy". Drugs.com. Retrieved 24 December 2018.
- ^ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 160. ISBN 978-0-85711-369-6.
{{cite book}}: CS1 maint: date format (link) - ^ Fischer, Janos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 463. ISBN 9783527607495.
- ^ "NADAC as of 2018-12-19". Centers for Medicare and Medicaid Services. Retrieved 22 December 2018.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- ^ "Carvedilol - Drug Usage Statistics". ClinCalc. 23 December 2019. Retrieved 11 April 2020.