Clinical data | |
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Trade names | Carbaglu, Ucedane |
Other names | (S)-2-ureidopentanedioic acid |
AHFS/Drugs.com | Monograph |
License data |
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Pregnancy category |
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Routes of administration | By mouth |
Drug class | Carbamoyl phosphate synthetase 1 (CPS 1) activator[1] |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 30% |
Protein binding | Undetermined |
Metabolism | Partial |
Elimination half-life | 4.3 to 9.5 hours |
Excretion | Fecal (60%) and kidney (9%, unchanged) |
Identifiers | |
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Chemical and physical data | |
Formula | C6H10N2O5 |
Molar mass | 190.155 g·mol−1 |
3D model (JSmol) | |
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Carglumic acid, sold under the brand name Carbaglu among others, is a medication used to treat high ammonia due to N-acetylglutamate synthase (NAGS) deficiency, propionic acidemia (PA) or methylmalonic acidemia (MMA).[1] It is taken by mouth.[1]
Common side effects include vomiting, abdominal pain, fever, tonsillitis, low red blood cells, diarrhea, infections, low red blood cells, low blood sugar, pancreatitis, electrolyte abnormalities, and headache.[1] Safety in pregnancy is unclear.[1] It is a carbamoyl phosphate synthetase 1 (CPS 1) activator, which works by activating an enzyme that breaks down ammonia.[1][2]
Carglumic acid was approved for medical use in Europe in 2003 and the United States in 2010.[1][2] It is available as a generic medication.[4] In the United Kingdom 60 tablets of 200 mg costs the NHS about £2,600 as of 2021.[4] This amount in the United States costs about 13,400 USD.[5]
References
edit- ^ a b c d e f g h i j k "Carbaglu- carglumic acid tablet". DailyMed. Archived from the original on 9 June 2021. Retrieved 9 June 2021.
- ^ a b c "Carbaglu EPAR". European Medicines Agency (EMA). Archived from the original on 9 June 2021. Retrieved 9 June 2021.
- ^ "Ucedane EPAR". European Medicines Agency (EMA). Archived from the original on 9 June 2021. Retrieved 9 June 2021.
- ^ a b BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1118. ISBN 978-0857114105.
- ^ "Carbaglu Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 20 April 2021. Retrieved 30 December 2021.