 | |
 | |
| Clinical data | |
|---|---|
| Trade names | Bumex, Burinex, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a684051 |
| License data |
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| Pregnancy category |
|
| Routes of administration | By mouth, intravenous, intramuscular |
| Drug class | Loop diuretic[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | Almost complete (~80%) |
| Protein binding | 97% |
| Metabolism | Liver |
| Elimination half-life | ~0.8 hours |
| Excretion | Kidney |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C17H20N2O5S |
| Molar mass | 364.42 g·mol−1 |
| 3D model (JSmol) | |
| |
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| (verify) | |
Bumetanide, sold under the trade name Bumex among others, is a medication used to treat swelling and high blood pressure.[1] This includes swelling as a result of heart failure, liver failure, or kidney problems.[1] It may work for swelling when other medications have not.[1] For high blood pressure it is not a preferred treatment.[1] It is taken by mouth, or by injection into a vein or muscle.[1] Effects generally begin within an hour and lasts for about six hours.[1]
Common side effects include dizziness, low blood pressure, low blood potassium, muscle cramps, and kidney problems.[1] Other serious side effects may include hearing loss and low blood platelets.[1] People with a sulfa allergy, may also be allergic to bumetanide.[1] Blood tests are recommended regularly for those on treatment.[1] Safety during pregnancy and breastfeeding is unclear.[3] Bumetanide is a loop diuretic and works by decreasing the reabsorption of sodium by the kidneys.[4][1]
Bumetanide was patented in 1968 and came into medical use in 1972.[5] It is available as a generic medication.[4] A month supply in the United Kingdom costs the NHS about £1.20 as of 2019.[4] In the United States the wholesale cost of this amount is about US$12.[6] In 2017, it was the 277th most commonly prescribed medication in the United States, with more than one million prescriptions.[7][8]
References edit
- ^ a b c d e f g h i j k l m n "Bumetanide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 8 April 2019.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Retrieved 8 September 2020.
- ^ "Bumetanide (Bumex) Use During Pregnancy". Drugs.com. Retrieved 8 April 2019.
- ^ a b c British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. pp. 225–226. ISBN 9780857113382.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 458. ISBN 9783527607495.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
- ^ "Bumetanide - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.