Clinical data | |
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Pronunciation | /ˌbrɪvəˈræsətəm/ BRIV-ə-RASS-ə-təm |
Trade names | Briviact, Nubriveo, Brivazen, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a616027 |
License data |
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Pregnancy category |
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Routes of administration | By mouth, intravenous |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | Nearly 100% |
Protein binding | ≤20% |
Metabolism | Hydrolysis by amidase, CYP2C19-mediated hydroxylation |
Metabolites | 3 inactive metabolites |
Elimination half-life | ≈9 hours |
Excretion | Kidneys (>95%)[1] |
Identifiers | |
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Chemical and physical data | |
Formula | C11H20N2O2 |
Molar mass | 212.293 g·mol−1 |
3D model (JSmol) | |
Specific rotation | [α]D −60° |
Melting point | 72 to 77 °C (162 to 171 °F) |
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Brivaracetam, sold under the brand name Briviact among others, is a medication used to treat epilepsy, specifically partial-onset seizures.[2] It is used in people over the age of 3 together with other epilepsy medicines.[2] It may be taken by mouth or injected into a vein.[4]
Common side effects include sleepiness, dizziness, tiredness, and nausea.[3] Other side effects may include suicide, psychosis, angioedema, and anxiety.[3] Use in pregnancy may harm the baby.[3] How it works is unclear; however, may related to synaptic vesicle protein 2A.[4] It is chemically similar to levetiracetam.[4]
Brivaracetam was approved for medical use in the United States and Europe in 2016.[3][2] In the United Kingdom 4 weeks of medications costs the NHS about £130 as of 2021.[5] This amount in the United States is about 1,200 USD.[6]
References
edit- ^ a b "Briviact- brivaracetam tablet, film coated Briviact- brivaracetam solution Briviact- brivaracetam injection, suspension". DailyMed. 15 May 2018. Archived from the original on 21 March 2021. Retrieved 25 January 2019.
- ^ a b c d "Briviact (in Italy: Nubriveo)". Archived from the original on 29 December 2021. Retrieved 11 January 2022.
- ^ a b c d e "DailyMed - BRIVIACT- brivaracetam tablet, film coated BRIVIACT- brivaracetam solution BRIVIACT- brivaracetam injection, suspension". dailymed.nlm.nih.gov. Archived from the original on 21 March 2021. Retrieved 11 January 2022.
- ^ a b c "Brivaracetam Monograph for Professionals". Drugs.com. Archived from the original on 26 July 2021. Retrieved 11 January 2022.
- ^ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 326. ISBN 978-0857114105.
- ^ "Briviact Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 11 January 2022.