Clinical data | |
---|---|
Pronunciation | /bəˈnæzəprɪl/ |
Trade names | Lotensin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692011 |
Pregnancy category |
|
Routes of administration | By mouth |
Drug class | ACE inhibitor[1] |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Protein binding | 96.7% |
Metabolism | Liver glucuronidation |
Elimination half-life | 10 hours[2] |
Excretion | Kidney and biliary |
Identifiers | |
| |
Chemical and physical data | |
Formula | C24H28N2O5 |
Molar mass | 424.497 g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Benazepril, sold under the brand name Lotensin among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease.[1] It is a reasonable initial treatment for high blood pressure.[1] It is taken by mouth.[1] Versions are available as the combinations benazepril/hydrochlorothiazide and benazepril/amlodipine.[1]
Common side effects include feeling tired, dizziness, cough, and light-headedness with standing.[1] Serious side effects may include kidney problems, low blood pressure, high blood potassium, and angioedema.[1] Use in pregnancy may harm the baby while use when breastfeeding maybe okay.[4] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[1]
Benazepril was patented in 1981 and came into medical use in 1990.[5] It is available as a generic medication.[1] A month supply in the United States costs about US$1.32 as of 2019.[6] In 2017, it was the 104th most commonly prescribed medication in the United States, with more than seven million prescriptions.[7][8]
References
edit- ^ a b c d e f g h i j k "Benazepril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 4 August 2020. Retrieved 3 March 2019.
- ^ Benowitz, Neal L. (2020). "11. Antihypertensive agents". In Katzung, Bertram G.; Trevor, Anthony J. (eds.). Basic and Clinical Pharmacology (15th ed.). New York: McGraw-Hill. p. 183. ISBN 978-1-260-45231-0. Archived from the original on 2021-10-10. Retrieved 2021-12-05.
- ^ Cite error: The named reference
WHO2020DDD
was invoked but never defined (see the help page). - ^ "Benazepril Pregnancy and Breastfeeding Warnings". Drugs.com. Archived from the original on 29 November 2020. Retrieved 3 March 2019.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 468. ISBN 9783527607495. Archived from the original on 2019-03-01. Retrieved 2019-03-01.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 2019-03-06. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Benazepril Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 3 March 2021. Retrieved 11 April 2020.