Wikipedia

User:Mr. Ibrahem/Azacitidine

< User:Mr. Ibrahem
Mr. Ibrahem/Azacitidine
Clinical data
Pronunciationay" za sye' ti deen
Trade namesVidaza, Azadine, Onureg
Other names5-Azacytidine, azacytidine, ladakamycin, 4-Amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one, U-18496, CC-486
AHFS/Drugs.comMonograph
MedlinePlusa607068
License data
Pregnancy
category
  • AU: X (High risk)[1]
Routes of
administration		Subcutaneous injection, intravenous, by mouth
Drug classNucleoside analog[2]
Legal status
Legal status
Pharmacokinetic data
Elimination half-life4 hr.[5]
Identifiers
  • 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
Chemical and physical data
FormulaC8H12N4O5
Molar mass244.207 g·mol−1
3D model (JSmol)
  • O=C1/N=C(\N=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N
  • InChI=1S/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1 checkY
  • Key:NMUSYJAQQFHJEW-KVTDHHQDSA-N checkY
  (verify)

Azacitidine, sold under the brand name Vidaza among others, is a medication used to treat myelodysplastic syndrome, acute myeloid leukaemia (AML), chronic myelomonocytic leukaemia.[6][7] It is given by injection into a vein or under the skin.[2]

Common side effects include nausea, low red blood cells, low platelets, fever, low white blood cells, diarrhea, low potassium, and bruises.[8] Other side effects may include liver problems, kidney problems, and tumor lysis syndrome.[8] Use in pregnancy may harm the baby.[8] It is a cytosine analogue which works by blocking DNA methylation.[6]

Azacitidine was approved for medical use in the United States in 2004 and Europe in 2008.[8][9] It is available as a generic medication.[7] In the United Kingdom 100 mg costs the NHS about £220 as of 2021.[7] In the United States this amount costs about 83 USD.[10]

References edit

  1. ^ "Azacitidine (Vidaza) Use During Pregnancy". Drugs.com. 5 May 2020. Archived from the original on 5 December 2020. Retrieved 12 August 2020.
  2. ^ a b "Azacitidine Monograph for Professionals". Drugs.com. Archived from the original on 5 March 2021. Retrieved 17 January 2022.
  3. ^ "Vidaza- azacitidine injection, powder, lyophilized, for solution". DailyMed. 2 March 2020. Archived from the original on 5 November 2021. Retrieved 27 September 2020.
  4. ^ "Onureg EPAR". European Medicines Agency. 20 April 2021. Archived from the original on 6 September 2021. Retrieved 6 September 2021.
  5. ^ Vallerand AH, Deglin JH (2009). Davis's drug guide for nurses. Philadelphia: F.A. Davis Company. pp. 204–206. ISBN 978-0-8036-1912-8.
  6. ^ a b c "Azacitidine". LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. National Institute of Diabetes and Digestive and Kidney Diseases. 2012. Archived from the original on 11 December 2021. Retrieved 17 January 2022.
  7. ^ a b c d BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 950. ISBN 978-0857114105.
  8. ^ a b c d e "DailyMed - VIDAZA- azacitidine injection, powder, lyophilized, for solution". dailymed.nlm.nih.gov. Archived from the original on 5 November 2021. Retrieved 17 January 2022.
  9. ^ "Vidaza". Archived from the original on 29 December 2021. Retrieved 17 January 2022.
  10. ^ "Azacitidine Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 17 January 2022.
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