| Combination of | |
|---|---|
| Atenolol | Beta blocker |
| Chlortalidone | Diuretic |
| Clinical data | |
| Trade names | Tenoretic, Tenoret, others |
| AHFS/Drugs.com | FDA Professional Drug Information |
| License data | |
| Routes of administration | By mouth |
| Legal status | |
| Legal status | |
Atenolol/chlorthalidone, also known as co-tenidone, is a combination medication used to treat high blood pressure.[3][4] It is made up of atenolol, a beta-blocker and chlortalidone, a diuretic.[5] It is not recommended as an initial treatment but may be used in those who are taking atenolol and chlortalidone individually.[6] It is taken by mouth.[3]
Common side effects include gastrointestinal upset and gout.[4] Serious side effects may include liver problems, pancreatitis, and psychosis.[4] Use is not recommended during pregnancy.[4] Use during breastfeeding may harm the baby.[3] Atenolol works by blocking β1-adrenergic receptors in the heart, thus decreasing the heart rate and workload.[4] Chlorthalidone works by increasing the amount of sodium lost by the kidneys.[3]
The combination was approved for medical use in the United States in 1984.[5] It is available as a generic medication.[4] A month supply in the United Kingdom costs the NHS less than 2 £ as of 2019.[4] In the United States the wholesale cost of this amount is about US$12.30.[7] In 2017, it was the 295th most commonly prescribed medication in the United States, with more than one million prescriptions.[8][9]
References
edit- ^ "Tenoret 50 mg/12.5 mg film coated tablets - Summary of Product Characteristics (SmPC)". (emc). 29 November 2019. Archived from the original on 22 September 2020. Retrieved 4 May 2020.
- ^ "WHOCC - ATC/DDD Index". www.whocc.no. Archived from the original on 1 July 2021. Retrieved 9 September 2020.
- ^ a b c d "DailyMed - atenolol and chlorthalidone tablet". dailymed.nlm.nih.gov. Archived from the original on 18 September 2015. Retrieved 18 April 2019.
- ^ a b c d e f g British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 153. ISBN 9780857113382.
- ^ a b "Atenolol and Chlorthalidone Tablets - FDA prescribing information, side effects and uses". Drugs.com. Archived from the original on 18 April 2019. Retrieved 18 April 2019.
- ^ "Atenolol Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 18 April 2019. Retrieved 18 April 2019.
- ^ "NADAC as of 2019-02-27". Centers for Medicare and Medicaid Services. Archived from the original on 6 March 2019. Retrieved 3 March 2019.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 12 February 2021. Retrieved 11 April 2020.
- ^ "Atenolol; Chlorthalidone - Drug Usage Statistics". ClinCalc. Archived from the original on 11 April 2020. Retrieved 11 April 2020.