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User:Mr. Ibrahem/Amisulpride

< User:Mr. Ibrahem

Mr. Ibrahem/Amisulpride
Clinical data
Trade namesSolian, Barhemsys, Socian, Deniban, others
Other namesAPD421
AHFS/Drugs.comMonograph
License data
Pregnancy
category
Routes of
administration		By mouth, intravenous
Drug classAtypical antipsychotics[3]
Legal status
Legal status
Pharmacokinetic data
Bioavailability48%[5][6]
Protein binding16%[6]
MetabolismLiver (minimal; most excreted unchanged)[6]
Elimination half-life12 hours[5]
ExcretionKidney[5] (23–46%),[7][8] Faecal[6]
Identifiers
  • 4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
Chemical and physical data
FormulaC17H27N3O4S
Molar mass369.48 g·mol−1
3D model (JSmol)
  • O=S(=O)(c1cc(c(OC)cc1N)C(=O)NCC2N(CC)CCC2)CC
  • InChI=1S/C17H27N3O4S/c1-4-20-8-6-7-12(20)11-19-17(21)13-9-16(25(22,23)5-2)14(18)10-15(13)24-3/h9-10,12H,4-8,11,18H2,1-3H3,(H,19,21) checkY
  • Key:NTJOBXMMWNYJFB-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Amisulpride, sold under the brand name Solian among others, is a medication used to treat and prevent postoperative nausea and vomiting (PONV) to treat schizophrenia.[3][9] It is taken by mouth or by injection into a vein.[3][9]

Common side effects include nausea, breast pain, sexual dysfunction, and low potassium.[3][9] Other side effects may include QT prolongation, high blood sugar, and abnormal lipids.[3][9] While its safety in pregnancy is unclear, it has caused harm with use in other animals.[10] It is an atypical antipsychotics and is believed to work by blocking the dopamine D2 and D3 receptors.[3]

Amisulpride has been in medical use since 1992.[11] It is available as a generic medication.[3] In the United Kingdom 60 pills of 400 mg costs about £42 as of 2021.[3] In the United States a vial of 5 mg costs about 45 USD.[12]

References edit

  1. ^ "Australian Product Information – Solian (Amisulpride) Tablets And Solution". TGA eBS. Archived from the original on 31 December 2019. Retrieved 10 May 2020.
  2. ^ a b "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com. 2 September 2020. Archived from the original on 28 January 2021. Retrieved 24 September 2020.
  3. ^ a b c d e f g h i j BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 415. ISBN 978-0857114105.
  4. ^ "Amisulpride 100 mg Tablets - Summary of Product Characteristics (SmPC)". (emc). 5 July 2019. Archived from the original on 26 February 2020. Retrieved 26 February 2020.
  5. ^ a b c Rosenzweig, P.; Canal, M.; Patat, A.; Bergougnan, L.; Zieleniuk, I.; Bianchetti, G. (2002). "A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers". Human Psychopharmacology. 17 (1): 1–13. doi:10.1002/hup.320. PMID 12404702. S2CID 23877366.
  6. ^ a b c d "Solian tablets and solution product information" (PDF). TGA eBusiness Services. Sanofi-Aventis Australia Pty Ltd. 27 September 2019. Archived from the original on 31 December 2019. Retrieved 26 February 2020.
  7. ^ Caccia, S (May 2000). "Biotransformation of Post-Clozapine Antipsychotics Pharmacological Implications". Clinical Pharmacokinetics. 38 (5): 393–414. doi:10.2165/00003088-200038050-00002. PMID 10843459. S2CID 68853079.
  8. ^ Noble, S; Benfield, P (December 1999). "Amisulpride: A Review of its Clinical Potential in Dysthymia". CNS Drugs. 12 (6): 471–483. doi:10.2165/00023210-199912060-00005.
  9. ^ a b c d e f "Amisulpride Monograph for Professionals". Drugs.com. Retrieved 14 January 2022.
  10. ^ "Amisulpride (Barhemsys) Use During Pregnancy". Drugs.com. Archived from the original on 28 January 2021. Retrieved 14 January 2022.
  11. ^ Advances in the Neurochemistry and Neuropharmacology of Tourette Syndrome. Academic Press. 27 November 2013. p. 318. ISBN 978-0-12-411561-3. Archived from the original on 14 January 2022. Retrieved 14 January 2022.
  12. ^ "Barhemsys Prices, Coupons & Patient Assistance Programs". Drugs.com. Retrieved 14 January 2022.
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