 | |
| Clinical data | |
|---|---|
| Pronunciation | /ælˈfjuːzoʊsɪn/ al-FEW-zoh-sin |
| Trade names | Uroxatral, others |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a64002 |
| Pregnancy category |
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| Routes of administration | By mouth (tablets) |
| Drug class | α1 adrenergic receptor blocker[1] |
| Legal status | |
| Legal status | |
| Pharmacokinetic data | |
| Bioavailability | 49% |
| Protein binding | 82–90% |
| Metabolism | Liver (CYP3A4-mediated) |
| Elimination half-life | 10 hours |
| Excretion | Feces (69%) and Urine (24%) |
| Identifiers | |
| |
| Chemical and physical data | |
| Formula | C19H27N5O4 |
| Molar mass | 389.456 g·mol−1 |
| 3D model (JSmol) | |
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| (verify) | |
Alfuzosin, sold under the brand name Uroxatral among others, is a medication used to treat benign prostatic hyperplasia (BPH).[1] It may be less effective than other medications in its class.[2] It may be used together with a 5α-reductase inhibitors.[1] It is taken by mouth once per day.[1]
Common side effects include lightheadedness, tiredness, and headache.[1] Other side effects include low blood pressure and QT prolongation.[1] Use is not recommended in those with significant liver problems.[1] It is a α1 adrenergic receptor blocker and works by relaxing the muscles in the prostate and bladder neck.[1]
Alfuzosin was patented in 1978 and approved for medical use in 1988.[3] It was approved for medical use in the United States in 2003.[1] In the United States it costs about 18 USD for 3 months.[4] In 2017, it was the 266th most commonly prescribed medication in the United States, with more than one million prescriptions.[5][6]
References edit
- ^ a b c d e f g h i j k "Alfuzosin Monograph for Professionals". Drugs.com. Archived from the original on 19 January 2021. Retrieved 14 July 2021.
- ^ Lepor H (August 2016). "Alpha-blockers for the Treatment of Benign Prostatic Hyperplasia". The Urologic Clinics of North America. 43 (3): 311–23. doi:10.1016/j.ucl.2016.04.009. PMC 2213889. PMID 27476124.
- ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 455. ISBN 9783527607495. Archived from the original on 2020-10-05. Retrieved 2020-09-19.
- ^ "Alfuzosin Prices, Coupons & Patient Assistance Programs". Drugs.com. Archived from the original on 5 July 2017. Retrieved 14 July 2021.
- ^ "The Top 300 of 2020". ClinCalc. Archived from the original on 18 March 2020. Retrieved 11 April 2020.
- ^ "Alfuzosin Hydrochloride - Drug Usage Statistics". ClinCalc. Archived from the original on 12 April 2020. Retrieved 11 April 2020.