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Single-nucleotide polymorphisms may fall within coding sequences of genes, non-coding regions of genes, or in the intergenic regions(regions between genes). SNPs within a coding sequence do not necessarily change the amino acid sequence of the protein that is produced, due to degeneracy of the genetic code.[1] - complete and added to live article
SNPs in the coding region are of two types: synonymous SNPs and non-synonymous SNPs. Synonymous SNPs do not affect the protein sequence, while non-synonymous SNPs change the amino acid sequence of protein.[2] -complete and added to live article
More than 600 million SNPs have been identified across the human genome within the world's population.[3]
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edit- ^ Spencer, Paige S.; Barral, José M. (2012). "Genetic code redundancy and its influence on the encoded polypeptides". Computational and Structural Biotechnology Journal. 1: e201204006. doi:10.5936/csbj.201204006. ISSN 2001-0370. PMC 3962081. PMID 24688635.
- ^ Chu, Duan; Wei, Lai (2019-04-16). "Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation". BMC cancer. 19 (1): 359. doi:10.1186/s12885-019-5572-x. ISSN 1471-2407. PMC 6469204. PMID 30991970.
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: CS1 maint: unflagged free DOI (link) - ^ "What are single nucleotide polymorphisms (SNPs)?: MedlinePlus Genetics". medlineplus.gov. Retrieved 2023-03-22.