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David H. Gutmann
discusses NF1 in a video for the Higher Education Channel (HEC-TV) in 2013.
Born
Cincinnati, Ohio
Alma materUniversity of Michigan
Known forNeurofibromatosis
Scientific career
InstitutionsWashington University in St. Louis; University of Michigan
Doctoral advisorJohn E. Niederhuber, MD
Other academic advisorsKenneth Fischbeck, MD; Francis S. Collins, MD, PhD

David H. Gutmann

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David Hillel Gutmann is the Donald O. Schnuck Family Professor and Director of the Neurofibromatosis Center at Washington University in St. Louis.[1] He is an international expert in Neurofibromatosis, pioneering the use of preclinical models to understand brain tumors and neurodevelopmental delays in children with NF1.

Early life and education

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Born in Michigan, David H. Gutmann spent summers during his high school career volunteering at the Henry Ford Hospital in Detroit, sparking his passion for medicine.[2] While receiving an undergraduate degree at the University of Michigan,[3] Gutmann was introduced to the budding field of genetics, the influence of which sowed seeds for his later research work.[4] As an undergraduate, he worked as a college disc jockey and attended numerous jazz concerts and events[5] in Ann Arbor, establishing a life-long love of jazz music.[6]


Further pursuing his education, Gutmann went on to complete his MD and PhD at the University of Michigan[3]. Under the guidance of Dr. John E. Niederhuber, he received his PhD in immunogenetics, graduating with distinction in 1986.[7] Gutmann then completed his residency training at the University of Pennsylvania in the lab of Dr. Kenneth Fischbeck, where he was mentored in neurogenetics.[3]


Returning to the University of Michigan for his postdoctoral fellowship in Human Genetics, Gutmann joined the lab of Dr. Francis S. Collins.[3] During this time, Collins and his team had recently cloned the NF1 gene.[7] Tasked with establishing the function of the NF1 gene, Gutmann identified the encoding protein, neurofibromin, and proceeded to investigate its function as a RAS regulator.[3]

Research and career

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Awards and honors

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  • 1993 March of Dimes Young Investigator Award, FASEB Summer
  • 1994 Peter A. Aron National Neurofibromatosis Foundation Award,
  • 1996 Decade of the Brain Plenary Session Speaker, American Academy of Neurology
  • 1998 Carolyn Farb Endowed Lecture in Neurofibromatosis
  • 1998 National Neurofibromatosis Foundation Crystal Award
  • 1999 Walker Lecturer in Neurofibromatosis
  • 1999 Eliason Teaching Award, Department of Neurology
  • 2001 Linse Block Neuro-oncology Visiting Professor, Mayo Clinic Foundation
  • 2002 National Neurofibromatosis Foundation Center of Excellence Award
  • 2003 Washington University School of Medicine Clinical Teacher of the Year Award[8]
  • 2006 Manuel R. Gomez Named Visiting Professor
  • 2007 Ninth Annual Arthur and Sonia Labatt Brain Tumor Research Centre Lecturer[9]
  • 2007 Award for Excellence in Pediatric Basic/Translational Research, Society for Neuro-Oncology[10]
  • 2008 Award for Excellence in Pediatric Translational Research, Society for Neuro-Oncology[10]
  • 2008 Takao Hoshino Lectureship, University of California – San Francisco[11]
  • 2010 Pfizer Visiting Professor, University of Virginia[12]
  • 2010 Washington University/Siteman Cancer Center “Rock Doc”[13]
  • 2012 Children’s Tumor Foundation Frederich Von Recklinghausen (Lifetime Achievement) Award[14]
  • 2013 Susan B. Stine Memorial Lectureship[11]
  • 2013 16th Annual Sara Hertafeld Memorial Lectureship[15]
  • 2014 8th Annual Riley Church Guest Professor, Stanford University[16]
  • 2017 Alexander von Humboldt Research Award[17]
  • 2017-2022 Berlin Institute of Health Einstein Visiting Fellowship[18]
  • 2018 Elected Fellow, American Academy of Neurology (AAN)[19]
  • 2019 Society for Neuro-Oncology Abjihit Guha Award and Lecture[20]
  • 2020 American Academy of Neurology Neuro-Oncology Investigator Award[21]
  • 2020 National Neurofibromatosis Network Advocate of Hope Award[22]

Selected publications

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  • Gutmann DH, Wood DL, Collins FS. Identification of the neurofibromatosis gene type 1 product. Proc Natl Acad Sci USA 88:9658-9662, 1991. PMID: 1946382
  • Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrent regulation of ras proteins in tumor cells from type 1 neurofibromatosis patients. Nature 356:713-715, 1992. PMID: 1570015
  • Listernick R, Louis DN, Packer RJ, Gutmann DH. Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force. Ann Neurol. 41:143-149, 1997. PMID: 9029062
  • Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, Gutmann DH. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Res. 63:8573-8577, 2003. PMID: 14695164
  • Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH. Proteomic analysis reveals hyperactivation of the mTOR pathway in NF1-associated human and mouse brain tumors.  Cancer Res. 65:2755-60, 2005.  PMID:  15805275
  • Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH. Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms.  Cell Stem Cell 1:443-457, 2007. PMID:  18371380
  • Hegedus B, Banerjee D, Yeh T-H, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH. Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma. Cancer Res. 68:1520-8, 2008.  PMID: 18316617
  • Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH. Increased JNK signaling in Neurofibromatosis-1 (Nf1) heterozygous microglia drives microglia activation and promotes optic glioma proliferation.  Cancer Res. 68:10358-10366, 2008.  PMID: 19074905
  • Lee DY, Yeh T-H, Emnett RJ, White CR, Gutmann DH. Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.  Genes & Development 24:2317-29, 2010. PMID:  20876733
  • Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH. Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner. Proc Natl Acad Sci USA 108:15996-6001, 2011.  PMID: 21896734
  • Lee DY, Gianino SM, Gutmann DH. Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell 22:131-8, 2012.  PMID:  22789544
  • Pong WW, Higer SB, Gianino SM, Emnett RJ, Gutmann DH. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Ann. Neurol. 73:303-8. 2013.  PMID:  23424002
  • Diggs-Andrews KA, Tokua K, Izumi I, Zorumski CF, Wozniak DF, Gutmann DH. Dopamine deficiency underlies learning deficits in neurofibromatosis-1 mice. Ann Neurol 73:309-15, 2013.  PMID:  23225063
  • Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH. Sex is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Ann Neurol 75:309-16, 2014.  PMID:  24375753
  • Chen YH, Gianino SM, Gutmann DH. Neurofibromatosis-1 regulation of neural stem cell proliferation and multi-lineage differentiation operates through distinct RAS effector pathways. Genes & Development 29:1677-82, 2015. PMID: 26272820
  • Chen Y-H, D’Agostino McGowan L, Cimino PJ, Dahiya S, Leonard JR, Lee DY, Gutmann DH. Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties. Cell Reports 10:1899-1912, 2015. PMID: 25772366
  • Toonen JA, Solga AC, Ma Y, Gutmann DH. Estrogen activation of microglia underlies the sexually-dimorphic differences in Nf1 optic glioma-induced retinal pathology. J Exp Med 214:17-25, 2017. PMID: 27923908
  • Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen Y-H, Dahiya S, Gutmann DH. Athymic mice reveal a requirement for T cell-microglia interactions in establishing a microenvironment supportive for Nf1 low grade glioma growth. Genes Dev 32: 491-496, 2018. PMID: 29632086
  • Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Dougherty JD, Cobb O, Gutmann DH. Human iPSC-derived neurons and cerebral organoids establish differential effects of germline NF1 gene mutations. Stem Cell Reports 14: 541-550, 2020.  PMID: 32243842
  • Guo X, Pan Y, Xiong M, Sanapala S, Anastasaki C, Cobb O, Dahiya S, Gutmann DH. Midkine activation of CD8+ cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. Nat Commun 11: 2177, 2020. PMID: 32358581.

References

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  1. ^ "Meet the Team". Neurofibromatosis (NF) Center. Retrieved 2020-06-16.
  2. ^ LIGHT, PATRICIA CORRIGAN, SPECIAL TO THE JEWISH. "Physician-researcher struggles with challenging 'Moonshot' problem". St. Louis Jewish Light. Retrieved 2020-07-01.{{cite web}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b c d e "About David Gutmann". www.mdc-berlin.de. Retrieved 2020-07-01.
  4. ^ "David Gutman, MD, PhD, Neurologist, Neurofibromatosis Specialist - Medical Professional Education Center". professionals.barnesjewish.org. Retrieved 2020-07-01.
  5. ^ Perkins, Terry. "Regina Carter brings jazz and therapy to Children's Hospital". news.stlpublicradio.org. Retrieved 2020-07-01.
  6. ^ "YouTube". www.youtube.com. Retrieved 2020-07-01.
  7. ^ a b Thorn, Sheila M. (August 2014). "Profile: David Gutmann: making science work for patients" (PDF). The Lancet, Neurology. Volume 13: Page 762. {{cite journal}}: |volume= has extra text (help)
  8. ^ "Students honor professors at awards ceremony | The Source | Washington University in St. Louis". The Source. 2003-04-11. Retrieved 2020-06-18.
  9. ^ Imagine 14-15: The Annual Scientific Report of the Arthur and Sonia Labatt Brain Tumor Research Centre at the Hospital for Sick Children. www.sickkids.ca/PDFs/Research/BTRC/75730-BTRC_2014_2015.pdf.
  10. ^ a b Imagine 14-15: The Annual Scientific Report of the Arthur and Sonia Labatt Brain Tumor Research Centre at the Hospital for Sick Children. www.sickkids.ca/PDFs/Research/BTRC/75730-BTRC_2014_2015.pdf.
  11. ^ a b "David H. Gutmann, MD, PhD, FAAN's Web Bio > Department of Pediatrics Faculty Biography". pediatrics.wustl.edu. Retrieved 2020-06-18.
  12. ^ Pfizer, compiler. MAP Directory of Award Recipients and Board Members. pfe-pfizercom-d8-prod.s3.amazonaws.com/responsibility/grants_contributions/MAP_Directory_111903.pdf.
  13. ^ "Siteman Cancer Center Honors Rock Docs". Neurofibromatosis (NF) Center. Retrieved 2020-06-18.
  14. ^ Children's Tumor Foundation Conference, 2012. 2012. Children's Tumor Foundation,www.ctf.org/images/uploads/NFConference_Program_Book_Electronic_FINAL.pdf.
  15. ^ "Grand Rounds - Neurology - University of Rochester Medical Center". www.urmc.rochester.edu. Retrieved 2020-06-18.
  16. ^ University, © Stanford; Stanford; California 94305 (2014-11-26). "What developmental neurobiology can teach us about pediatric neuro-oncology". Wu Tsai Neurosciences Institute. Retrieved 2020-06-18.{{cite web}}: CS1 maint: numeric names: authors list (link)
  17. ^ www.humboldt-foundation.de https://www.humboldt-foundation.de/pls/web/pub_hn_query.humboldtianer_details?p_externe_id=3052756&p_lang=en&p_pattern=gutmann. Retrieved 2020-06-18. {{cite web}}: Missing or empty |title= (help)
  18. ^ "David Gutmann – Einstein Foundation Berlin". www.einsteinfoundation.de. Retrieved 2020-06-18. {{cite web}}: no-break space character in |title= at position 14 (help)
  19. ^ "2018 FAANs". www.aan.com. Retrieved 2020-06-18.
  20. ^ "David Gutmann Receives Neuro-Oncology Award - The ASCO Post". www.ascopost.com. Retrieved 2020-06-18.
  21. ^ Community, Nature Research Cancer. "David H. Gutmann, MD, PhD, FAAN". Nature Research Cancer Community. Retrieved 2020-06-18.
  22. ^ Holleman, Joe. "Wash U. doctor lauded for nervous system research". STLtoday.com. Retrieved 2020-06-18.
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