Norepinephrine Transporter (NET)
Brief introduction
Structure
editFunction
edit- norepinenphrine
Transport Mechanisms
editLocation in the Nervous System
editRegulation
editNET Gene
editGene Structure
editNET SNPs
edit- briefly- what SNPs are and why nonsynonymous SNPs are areas of interest for researchers
- evidence suggesting relationship between SNPs and disorders such as ADHD and depression
- only established relationship is between missense (nonsynonymous) polymorphism Ala457Pro and orthostatic intolerance (source: Tellioglu) [see below for OI]
- table of some SNPs (GoogleBooks- Reith)
Clinical Significance
edit- research with ADHD and depression etc. has yielded evidence but nothing has been proven yet (source: Tellioglu)
Orthostatic Intolerance
edit- SNP Ala457Pro
Therapeutic Potential
editNorepinephrine reuptake inhibitor
edit- briefly, what it is and how it affects the NET, then below name medications for each condition
Depression
editADHD
editSchizophrenia
editPsychostimulants
editCocaine
editAmphetamines
editFurther Research
edit- Understanding mental illness
See Also
editReferences
edit- Tellioglu T, Robertson D (November 2001). "Genetic or acquired deficits in the norepinephrine transporter: current understanding of clinical implications". Expert Rev Mol Med 2001: 1–10. doi:10.1017/S1462399401003878. PMID 14987367.
- Haenisch B, Bonisch H (March 2011). "Depression and antidepressants: Insights from knockout of dopamine, serotonin or noradrenaline re-uptake transporters". Pharmacology & Therapeutics 2011: 129-3. doi:10.1016/j.pharmthera.2010.12.002.
- Zhou J (December 2004). "Norepinephrine transporter inhibitors and their therapeutic potential". Drugs Future 2004: 29-12. PMC 1518795.
- Oaks AW, Sidhu A (April 2011). "Synuclein modulation of monoamine transporters". FEBS Letters 2011: 585-7. doi:10.1016/j.febslet.2011.03.009
Division of Workload
editWe have decided to divide the research into topics then meet whenever possible to create a cohesive Wikipedia page as a group.