User:Lizbeth.nunez/sandbox

History and Reasons for the Model

History of the Model

Date	Event
September 1978	First study tested to find correlation between obesity and palatable foods high in fats and lipids, but no conclusion could be reached.^[1]
1984
1995
June 2002	Göttingen minipig "pilot" study: published paper on a three month long experiment testing a nonrodent model to see if results could be accepted in DIO research or be compared to results of those studies where rodents were tested.^[2]
2007	Continued exploration of diet-induced obesity led to a study of rats as a potential model subject. This genomic based study induced obesity in rats and subsequently analyzed RNA microarrays to characterize the rats metabolic response and resultant insulin sensitivity.
2008
2009	The model is used to challenge beliefs about the causes of obesity in the population, as a group of scientists decided to test the notion that obesity is a result of overnutrition and could be controlled by limiting meal sizes.^[3]
2010	Continuing the trend of the model’s usage in determining causes of obesity, a group of researchers notice the changes across the diets of several Americans and conduct an experiment to understand why obesity was up when fat consumption was down. For this, they investigate the connection between the types of fat, meal timings and size, and weight gain as well as the reversibility of diet-induced obesity.^[4]
July 2011	Different Diet Stimuli: Diets varying from hyperlipic, hypercaloric, cholesterol-rich, and cafeteria diets were tested on rodents to see which had the most impact on body size and to determine differences between metabolic responses in rodents and humans.^[5]
2012	A 2012 study further explored the viability of the diet-induced obesity model by testing several mice for their reactivities to a high-caloric diet. The resulting data found some mice (the B6 mouse) responded to diet-induced obesity most similarly to humans with regards to several parameters including fat content, relative organ size, and general body composition.

^ Faust, I. M., Johnson, P. R., Stern, J. S., & Hirsch, J. (1978). Diet-induced adipocyte number increase in adult rats: a new model of obesity. The American journal of physiology, 3, E279-86.
^ Olholm Larsen, Marriane; Rolin, Bidda; Wilkin, Michael; Carr, Richard David; Svendsen, Ove (June 2002). "High-Fat High-Energy Feeding Impairs Fasting Glucose and Increases Fasting Insulin Levels in the Göttingen Minipig". Annals of the New York Academy of Science. 967: 414-423. doi:10.1111/j.1749-6632.2002.tb04297.x. {{cite journal}}: |access-date= requires |url= (help)
^ Furnes, M. W., Zhao, C. M., & Chen, D. (2009). Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young rats. Obesity surgery, 10, 1430–1438.
^ Niloofar, Hariri; Thibault, Louise. "High-fat diet-induced obesity in animal models". Nutrition Research Reviews. 23.
^ Campos Rosini, Tiago; Sanchez Ramos de Silva, Adelino; de Moraes, Camila (February 10, 2012). "Diet-induced obesity: rodent model for the study of obesity-related disorders". ScienceDirect. 58 (3). {{cite journal}}: |access-date= requires |url= (help)

[1] Faust, I. M., Johnson, P. R., Stern, J. S., & Hirsch, J. (1978). Diet-induced adipocyte number increase in adult rats: a new model of obesity. The American journal of physiology, 3, E279-86.

[2] Olholm Larsen, Marriane; Rolin, Bidda; Wilkin, Michael; Carr, Richard David; Svendsen, Ove (June 2002). "High-Fat High-Energy Feeding Impairs Fasting Glucose and Increases Fasting Insulin Levels in the Göttingen Minipig". Annals of the New York Academy of Science. 967: 414-423. doi:10.1111/j.1749-6632.2002.tb04297.x. {{cite journal}}: |access-date= requires |url= (help)

[3] Furnes, M. W., Zhao, C. M., & Chen, D. (2009). Development of obesity is associated with increased calories per meal rather than per day. A study of high-fat diet-induced obesity in young rats. Obesity surgery, 10, 1430–1438.

[4] Niloofar, Hariri; Thibault, Louise. "High-fat diet-induced obesity in animal models". Nutrition Research Reviews. 23.

[5] Campos Rosini, Tiago; Sanchez Ramos de Silva, Adelino; de Moraes, Camila (February 10, 2012). "Diet-induced obesity: rodent model for the study of obesity-related disorders". ScienceDirect. 58 (3). {{cite journal}}: |access-date= requires |url= (help)

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