FAM153A, family with sequence similarity 153 member B, is a protein that in humans is encoded by the FAM153A gene. Its known aliases are NY-REN-7, NY-REN-7 antigen, and renal carcinoma antigen NY-REN-7.[1] It is moderately expressed in most tissues, with high expression in the testis and spleen.[2] This protein is conserved exclusively in primates, including new-world and old-world monkeys.
Gene
editFAM153A is a protein-coding with little characterization. It is located on the minus strand of chromosome 5(5q35.3).[3] It spans 90,189 bases on the minus strand and contains 21 exons.[4]
Protein
editThis protein consists of 310 amino acids and is predicted to be coiled containing four disordered regions. It has a predicted molecular weight of approximately 34.7 kDa and an isoelectric point of 4.68.[5] It is predicted to be an intracellular protein, localizing to the nucleus and contains one predicted nuclear location signal.[6][7] This protein is highly negatively charged compared to standard human proteins.[8]
Variants
editFAM153A has two other variants: variant 1 and variant 2. Variant 1 consists of 310 amino acids (2176 bp). Variant 2 consists of 387 amino acids (2030 bp).[9] Variant 1 is identical to the FAM153A but contains 240 more nucleotides in the mRNA.[10]
Expression
editFAM153A is expressed across most body tissues at low to moderate levels, with increased expression in the spleen and testis.[1] It is also highly expressed in the brain (cerebellum), ovary, and testes. Fetal development data shows expression at high levels in the adrenal tissue from 0-20 weeks.[11] Antibody staining showed either strong or moderate cytoplasmic staining in the heart muscle, testis, kidney and pancreas, in addition to nuclear staining in the heart and kidney tissues.[12]
Homology and Evolution
editParalogs
editFAM153A has two known [[1]]: FAM153B and FAM153C. FAM153B is found in new and old-world monkeys, whereas FAM153C is only found in new-world monkeys.
Orthologs
editFAM153A has distantly related [[2]] exclusively in primates. It is primarily conserved in primates and new world monkeys, which diverged from humans approximately 15.2 and 28.8 million years ago respectively. The gene is found in one old-world monkey, the common marmoset, which diverged from humans approximately 43 million years ago.
Interacting Proteins
editExperimental findings show that FAM153A interacts with DYNLL1, FAM153B, and ROPN1.[13][14]
- ^ a b "NCBI gene". National Center for Biotechnology Information. National Library of Medicine. Retrieved 25 June 2023.
- ^ "NCBI gene". National Center for Biotechnology Information. National Library of Medicine. Retrieved 25 June 2023.
- ^ "Genecards". Genecards. Weizmann Institute of Science. Retrieved 17 June 2023.
- ^ "Genecards". Genecards. Weizmann Institute of Science. Retrieved 17 June 2023.
- ^ "Expasy". Expasy. Swiss Institute of Bioinformatics. Retrieved 11 July 2023.
- ^ "Genecards". Genecards. Weizmann Institute of Science. Retrieved 17 June 2023.
- ^ "myhits motif scan". myhits. Swiss Institute of Bioinformatics. Retrieved 11 July 2023.
- ^ "SAPS Sequence Statistics". EMBL-EBI. EMBL. Retrieved 11 July 2023.
- ^ "Genecards". Genecards. Weizmann Institute of Science. Retrieved 17 June 2023.
- ^ "Genecards". Genecards. Weizmann Institute of Science. Retrieved 17 June 2023.
- ^ "NCBI Geo". National Center for Biotechnology Information. National Library of Medicine. Retrieved 2 July 2023.
- ^ "FAM153A". Human Protein Atlas. The Human Protein Atlas Project. Retrieved 3 July 2023.
- ^ "PISCQUIC viewer". PISCQUIC. EMBL-EBI. Retrieved 20 July 2023.
- ^ "FAM153A protein (human)". STRING interaction network. Global Biodata Coalition. Retrieved 20 July 2023.