User:Kviveros/sandbox

Zebrafish

Zebrafish are commonly used for the basic study and develpoment of various cancers. Used to explore the immune system and genetic strains. They are low in cost, small size, fast reproduction rate, and able to observe cancer cells in real time. Humans and Zebrafish soild neoplasm similarities which is why they are used for research. The National library of Medicine shows manys examples of the types of cancer Zebrafish are used in. The use of Zebrafish have allowed them to find differences between MYC-driven pre-B vs T-ALL and be exploited to discover novel pre-B ALL therapies on Acute lymphocytic leukemia.^[1]^[2]

Zebrafish are a freshwater fish and are from the minnow family.^[3] They are commonly used for cancer research.

The National library of Medicine also explains how a neoplasm is difficult to diagagnoise at a early stage. Understanding the molecluar mechaniam of digestive tract tumorigenesis and searching for new treatments is the current research. Zebrafish and humans share similar gastric cancer cells in the gastric cancer xenotransplantation model.This allowed reserchers to find that Triphala could inhibit the growth and metastasis of gastric cancer cells. Since Zebrafish liver cancer ganes are related with humans they have become widely used in liver cancer search, as will as many other cancers.^[4]

^ Li, Zhitao; Zheng, Wubin; Wang, Hanjin; Cheng, Ye; Fang, Yijiao; Wu, Fan; Sun, Guoqiang; Sun, Guangshun; Lv, Chengyu; Hui, Bingqing (2021-03-15). "Application of Animal Models in Cancer Research: Recent Progress and Future Prospects". Cancer Management and Research. 13: 2455–2475. doi:10.2147/CMAR.S302565. ISSN 1179-1322. PMC 7979343. PMID 33758544.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Workman, P.; Aboagye, E. O.; Balkwill, F.; Balmain, A.; Bruder, G.; Chaplin, D. J.; Double, J. A.; Everitt, J.; Farningham, D. a. H.; Glennie, M. J.; Kelland, L. R. (2010-05-25). "Guidelines for the welfare and use of animals in cancer research". British Journal of Cancer. 102 (11): 1555–1577. doi:10.1038/sj.bjc.6605642. ISSN 1532-1827. PMC 2883160. PMID 20502460.
^ "Zebrafish", Wikipedia, 2022-04-17, retrieved 2022-05-04
^ Tsering, Jokyab; Hu, Xianda (2018). "Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model". BioMed Research International. 2018: 7046927. doi:10.1155/2018/7046927. ISSN 2314-6141. PMC 6311269. PMID 30643816.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[1] Li, Zhitao; Zheng, Wubin; Wang, Hanjin; Cheng, Ye; Fang, Yijiao; Wu, Fan; Sun, Guoqiang; Sun, Guangshun; Lv, Chengyu; Hui, Bingqing (2021-03-15). "Application of Animal Models in Cancer Research: Recent Progress and Future Prospects". Cancer Management and Research. 13: 2455–2475. doi:10.2147/CMAR.S302565. ISSN 1179-1322. PMC 7979343. PMID 33758544.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[2] Workman, P.; Aboagye, E. O.; Balkwill, F.; Balmain, A.; Bruder, G.; Chaplin, D. J.; Double, J. A.; Everitt, J.; Farningham, D. a. H.; Glennie, M. J.; Kelland, L. R. (2010-05-25). "Guidelines for the welfare and use of animals in cancer research". British Journal of Cancer. 102 (11): 1555–1577. doi:10.1038/sj.bjc.6605642. ISSN 1532-1827. PMC 2883160. PMID 20502460.

[3] "Zebrafish", Wikipedia, 2022-04-17, retrieved 2022-05-04

[4] Tsering, Jokyab; Hu, Xianda (2018). "Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model". BioMed Research International. 2018: 7046927. doi:10.1155/2018/7046927. ISSN 2314-6141. PMC 6311269. PMID 30643816.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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