User:JunglesKy/sandbox

Kylie's Edits

--GOAL: MAKE ARTICLE MORE READ-ABLE AND INCORPORATE RELEVANT IMAGES--

-Removed the hyperlink at the top of the page for an obscure Turkish film entitled "Inflame"--irrelevant information that added clutter

-Switched photo at the top of the page from a histology slide to an example of a foot experiencing inflammation

-Added to the inflammatory disorders section and added images of some of the examples (Asthma and Colitis)

-Corrected misspellings throughout article and removed extraneous sentences

Cardinal signs[edit | edit source]

The classic signs and symptoms of acute inflammation:

English	Latin
Redness	Rubor*
Swelling	Tumor*
Heat	Calor*
Pain	Dolor*
Loss of function	Functio laesa**
All the above signs may be observed in specific instances, but no single sign must, as a matter of course, be present. These are the original, or "cardinal signs" of inflammation.* Functio laesa is an antiquated notion, as it is not unique to inflammation and is a characteristic of many disease states.**

Acute inflammation is a short-term process, usually appearing within a few minutes or hours and begins to cease upon the removal of the injurious stimulus. It involves a coordinated response of various immune, endocrine and neurological mediators of acute inflammation. In a normal healthy response, it becomes activated, clears the pathogen, begins the repair process, and then ceases. It is characterized by the following five cardinal signs, which were derived from Latin:

• Dolor (pain)
• Calor (heat)
• Rubor (redness)
• Tumor (swelling)
• Functio laesa (loss of function)

*An acronym that may be used to remember the key symptoms is "PRISH", for pain, redness, immobility (loss of function), swelling and heat.

The first four (classical signs) were described by Celsus (ca. 30 BC–38 AD), while loss of function was added later by Galen even though the attribution is disputed and the origination of the fifth sign has also been ascribed to Thomas Sydenham and Virchow.

Redness and heat are due to increased blood flow at body core temperature to the inflamed site; swelling or edema is caused by accumulation of fluid; pain is due to the release of chemicals such as bradykinin and histamine that stimulate nerve endings. Loss of function has multiple causes.