 | It has been suggested that this page be merged into Human immunodeficiency virus type 1 dimerization initiation site, Human immunodeficiency virus type 1 major splice donor, Human immunodeficiency virus type 1 stem-loop 3 Psi packaging signal and Human immunodeficiency virus type 1 stem-loop 4 packaging signal. (Discuss) Proposed since September 2008. |
| Human immunodeficiency virus type 1 dimerisation initiation site | |
|---|---|
 Predicted secondary structure and sequence conservation of HIV-1_DIS | |
| Identifiers | |
| Symbol | HIV-1_DIS |
| Alt. Symbols | Retroviral_psi |
| Rfam | RF00175 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Viruses |
| SO | SO:0000233 |
| PDB structures | PDBe |
Retroviral Psi packaging element is a cis-acting RNA element identified in the genomes of the retroviruses Human immunodeficiency virus (HIV) [2] and Simian immunodeficiency virus (SIV)[3] It is involved in regulating encapsidation of the retroviral RNA, an essential step in replication. [4] [5] [6] [7]
This RNA element is known to have a secondary structure composed of four hairpins called SL1 to SL4 (SL is for Stem-loop). It has been shown that SL1 may provide a secondary binding site for the viral Rev protein [8]. Each of the stem loops SL1 [9], SL2 [10], SL3 [11][12] and SL4 [13] has been independently expressed and structurally characterised.
References
edit- ^ Baba S, Takahashi K, Noguchi S, Takaku H, Koyanagi Y, Yamamoto N, Kawai G (2005). "Solution RNA structures of the HIV-1 dimerization initiation site in the kissing-loop and extended-duplex dimers". J Biochem. 138 (5): 583–92. doi:10.1093/jb/mvi158. PMID 16272570.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lever A, Gottlinger H, Haseltine W, Sodroski J (1989). "Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions". J Virol. 63 (9): 4085–7. PMC 251012. PMID 2760989.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Strappe PM, Greatorex J, Thomas J, Biswas P, McCann E, Lever AM (2003). "The packaging signal of simian immunodeficiency virus is upstream of the major splice donor at a distance from the RNA cap site similar to that of human immunodeficiency virus types 1 and 2". J Gen Virol. 84 (9): 2423–30. doi:10.1099/vir.0.19185-0.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ McBride MS, Panganiban AT (1997). "Position dependence of functional hairpins important for human immunodeficiency virus type 1 RNA encapsidation in vivo". J. Virol. 71 (3): 2050–8. PMC 191293. PMID 9032337.
- ^ McBride MS, Schwartz MD, Panganiban AT (1997). "Efficient encapsidation of human immunodeficiency virus type 1 vectors and further characterization of cis elements required for encapsidation". J. Virol. 71 (6): 4544–54. PMC 191676. PMID 9151848.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ McBride MS, Panganiban AT (1996). "The human immunodeficiency virus type 1 encapsidation site is a multipartite RNA element composed of functional hairpin structures". J. Virol. 70 (5): 2963–73. PMC 190155. PMID 8627772.
- ^ Lever AM (2007). "HIV-1 RNA packaging". Adv. Pharmacol. Advances in Pharmacology. 55: 1–32. doi:10.1016/S1054-3589(07)55001-5. ISBN 9780123736109. PMID 17586311.
- ^ Gallego J; Greatorex J; Zhang H; et al. (2003). "Rev binds specifically to a purine loop in the SL1 region of the HIV-1 leader RNA". J. Biol. Chem. 278 (41): 40385–91. doi:10.1074/jbc.M301041200. PMID 12851400.
{{cite journal}}: Unknown parameter|author-separator=ignored (help)CS1 maint: unflagged free DOI (link) - ^ Lawrence DC, Stover CC, Noznitsky J, Wu Z, Summers MF (2003). "Structure of the intact stem and bulge of HIV-1 Psi-RNA stem-loop SL1". J. Mol. Biol. 326 (2): 529–42. doi:10.1016/S0022-2836(02)01305-0. PMID 12559920.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Amarasinghe GK, De Guzman RN, Turner RB, Chancellor KJ, Wu ZR, Summers MF (2000). "NMR structure of the HIV-1 nucleocapsid protein bound to stem-loop SL2 of the psi-RNA packaging signal. Implications for genome recognition". J. Mol. Biol. 301 (2): 491–511. doi:10.1006/jmbi.2000.3979. PMID 10926523.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Zeffman A, Hassard S, Varani G, Lever A (2000). "The major HIV-1 packaging signal is an extended bulged stem loop whose structure is altered on interaction with the Gag polyprotein". J Mol Biol. 297 (4): 877–93. doi:10.1006/jmbi.2000.3611. PMID 10736224.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Pappalardo L, Kerwood DJ, Pelczer I, Borer PN (1998). "Three-dimensional folding of an RNA hairpin required for packaging HIV-1". J. Mol. Biol. 282 (4): 801–18. doi:10.1006/jmbi.1998.2046. PMID 9743628.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Kerwood DJ, Cavaluzzi MJ, Borer PN (2001). "Structure of SL4 RNA from the HIV-1 packaging signal". Biochemistry. 40 (48): 14518–29. doi:10.1021/bi0111909. PMID 11724565.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
See also
editHuman immunodeficiency virus type 1 dimerization initiation site
Human immunodeficiency virus type 1 major splice donor
Human immunodeficiency virus type 1 stem-loop 3 Psi packaging signal
Human immunodeficiency virus type 1 stem-loop 4 packaging signal
External links
editCategory:Cis-regulatory RNA elements
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