| Ribosomal protein L20 leader | |
|---|---|
 Predicted secondary structure and sequence conservation of L20_leader | |
| Identifiers | |
| Symbol | L20_leader |
| Rfam | RF00558 |
| Other data | |
| RNA type | Cis-reg; leader |
| Domain(s) | Bacteria |
| SO | SO:0000233 |
| PDB structures | PDBe |
L20 ribosomal protein leader is a ribosomal protein leader involved in the ribosome biogenesis. It is used as an autoregulatory mechanism to control the concentration of ribosomal proteins L20. The structure is located in the 5′ untranslated regions of mRNAs encoding initiation factor 3 followed by ribosomal proteins L35 and L20 (infC-rpmI-rplT). A Rho-independent transcription terminator structure that is probably involved in regulation is included at the 3′ end. This family is a putative ribosomal protein leader autoregulatory structure[1] found in B. subtilis and other low-GC Gram-positive bacteria. A second example were predicted in Deltaproteobacteria with bioinformatic approaches. [2] In this structure were similarities between the rRNA binding site of the L20 ribosomal protein and the L20 ribosomal protein leader binding site detected.[2]
See also
editReferences
edit- ^ Zengel JM, Lindahl L (1994). "Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli". Progress in Nucleic Acid Research and Molecular Biology. Progress in Nucleic Acid Research and Molecular Biology. 47: 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
- ^ a b Eckert, I; Weinberg, Z (24 May 2020). "Discovery of 20 novel ribosomal leader candidates in bacteria and archaea". BMC Microbiology. 20 (130). doi:10.1186/s12866-020-01823-6.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
editCategory:Ribosomal protein leader
 | This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. |