(R)-Dysidazirine is a organic compound with formula C19H33NO2. It was discovered as a natural product in 1988 in the marine sponge Dysidea fragilis[1]. Chemically it is a 2H-azirine derivative.
![](http://upload.wikimedia.org/wikipedia/commons/thumb/d/d8/Disidazirina.jpg/220px-Disidazirina.jpg)
(R)-Dysidazirine synthesis was reported for the first time in 1995[2]. The data for the synthetic compound and natural product perfectly matched. except for the specific rotation. Apparently, the natural (R)-dysidazirine was only 89% optically pure
Dysidazirine exhibits potent in vitro antifungal activity against the pathogenic yeast Candida albicansItalic text. It also inhibits cultured HCT-116 human colon cancer cells.
References
edit- ^ "Despite my high ring strain, I'm pretty stable. What molecule am I?". ACS.org. American Chemical Society. Retrieved 18 November 2022.
- ^ Davis, Franklin A., Venkat Reddy, G. and Liu, Hu (1995). "Asymmetric Synthesis of 2H-Azirines: First Enantioselective Synthesis of the Cytotoxic Antibiotic (R)-(-)-Dysidazirine". J. Am. Chem. Soc. 117, 12: 3651–3652.
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