| Small nucleolar RNA SNORD10 | |
|---|---|
| SNORD10 | |
| Identifiers | |
| Symbol | SNORD10 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; CD-box; |
| PDB structures | PDBe |
SNORD10 (also known as snoRNA mgU6-77) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.
SNORD10 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). It directs the site-specific 2'-O-methylation of residue 77 in U6 small nuclear RNA as well as residue 2970 in 28S of Xenopus oocytes [1]
SNORD10 is located in a cluster with SNORD48 (upstream) and SNORD67 (downstream) in EIF4A1, the eukaryotic translation initiation factor 4A. This association with SNORD48 and SNORD67 is evolutionarily recent. In vertebrates other than Eutheria, EIF4A1 harbors SNORD10 only. While SNORD10 homologs were detected in B. floridae, P. marinus and C. milii, there are putative homologs in S. purpuratus, S.kowalevskii and even A. californica, which, however, are not located in an intron of EIF4A1. The snoOPY database, furthermore, lists the C. elegans gene [2] T03F7.8 as a homolog.
References
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Tycowski, K T and You, Z H and Graham, P J and Steitz, J A (1998). "Modification of U6 spliceosomal RNA is guided by other small RNAs". Mol.\ Cell. 2 (5): 629–638. doi:10.1016/S1097-2765(00)80161-6. PMID 9844635.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ "Caenorhabditis_elegans snoRNA :T03F7.8".