| Small nucleolar RNA SNORA53 | |
|---|---|
 | |
| Identifiers | |
| Symbol | SNORA53 |
| Rfam | RF00563 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; HACA-box; |
| PDB structures | PDBe |
The snoRNA ACA53 belongs to the H/ACA family of pseudouridylation guide snoRNAs. This H/ACA box RNA was cloned by Kiss et al. (2004) [1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. RNA residues targeted for pseudouridylation by this molecule have not been identified. It has a length well above 200nt, which is exceptionally large for an otherwise inconspicuous box H/ACA snoRNA.
Experimental surveys for snoRNAs have uncovered SNORA53 homologs in human [1], rhesus [2] , platypus (Oa1744) [3], and chicken (GGN66) [4]. Orthologous sequences across the tetrapoda are reported in the snoOPY database. SNORA53 is one of the most divergent snoRNAs in both sequence and structure. Our systematic survey records SNORA53 sequences throughout the metazoa. Across deuterostomes, it is located in an intron of the highly conserved mitochondrial phosphate carrier SLC53A3. The Strongylocentrotus purpuratus candidate contains an insert almost 1700 nt in length. It remains unclear, however, whether this is an artifact in the genome assembly.
References
edit- ^ a b Kiss, Arnold M.; Jády, Beáta E.; Bertrand, Edouard; Kiss, Tamás (2004). "Human Box H/ACA Pseudouridylation Guide RNA Machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- ^
Zhang, Y. and Liu, J. and Jia, C. and Li, T. and
Wu, R. and Wang, J. and Chen, Y. and Zou, X. and
Chen, R. and Wang, X. J. and Zhu, D. (2010). "Systematic identification and evolutionary features of
rhesus monkey small nucleolar RNAs". BMC Genomics. 11: 61. PMID 20100322.
{{cite journal}}: line feed character in|author=at position 49 (help); line feed character in|title=at position 55 (help)CS1 maint: multiple names: authors list (link) - ^
Schmitz, J and Zemann, A and Churakov, G and Kuhl, H
and Gr\"utzner, F and Reinhardt, R and Brosius, J. (2008). "Retroposed SNOfall--A mammalian-wide comparison of
platypus snoRNAs". Genome Res. 18: 1005–1010. PMID 18463303.
{{cite journal}}: line feed character in|author=at position 53 (help); line feed character in|title=at position 51 (help)CS1 maint: multiple names: authors list (link) - ^
Zhang, Yong and Wang, Jie and Huang, Shoujun and
Zhu, Xiaopeng and Liu, Jun and Yang, Ning and
Song, Dandan and Wu, Rimao and Deng, Wei and Skogerb\o (2009). "Systematic identification and characterization of
chicken (\emphGallus gallus) ncRNAs". Nucleic Acids Res. 37: 6562–6574. PMID 19720738.
{{cite journal}}: Text "Geir and Wang, Xiu-Jie and Chen, Runsheng and Zhu, Dahai" ignored (help); line feed character in|author=at position 49 (help); line feed character in|title=at position 50 (help)CS1 maint: multiple names: authors list (link)