Hermann Agis received his master degree in biotechnology in 2007 at the University of Natural Resources and Life Sciences (BOKU), Vienna. In 2011, he successfully finished his PhD at the Medical University of Vienna (MedUni Vienna). From 2013-2014, he was a visiting scholar at the Dental School of the University of Michigan, where he focused on the cellular mechanisms underlying oral soft tissue augmentation. In 2014, he received the venia dozendi (Privatdozent) from the MedUni Vienna. Currently, he is head of the Competence Center for Tissue Engineering and Cell-Based Therapies, University Clinic of Dentistry, MedUni Vienna. 2017 he was promoted to Associate Professor. His research focuses on oral tissue engineering. He was board member of the Young Scientist Association of the Medical University of Vienna (YSA) from 2010-2012. In 2011, he was elected for president of the YSA. He received several awards and fellowships including the Rudolf Slavicek Award of the Austrian Society of Dentistry, the Erwin-Schrödinger Fellowship of the Austrian Science Fund, as well as the Robert Frank Award by the CED-IADR. In 2013, he was selected as Mentee for the Austrian Scientists and Scholars in North America (ASCINA) Mentoring Program. In 2016, he became founding member of the ECTS Academy. 2017, he became faculty member of the F1000.
Hermann Agis: Peer-reviewed publications of the last 5 years (2014-2019)
1. Janjić K, Cvikl B, Schädl B, Moritz A, Agis H. (2019) The impact of collagen membranes on 3D gingival fibroblast toroids. BMC Oral Health. 22;19(1):48. https://doi.org/10.1186/s12903-019-0736-2
2. Janjić K, Schellner A, Engenhart A, Kernstock K, Schädl B, Moritz A, Agis H. (2019) Angiopoietin-like 4 production upon treatment with hypoxia and L-mimosine in periodontal fibroblasts. J Periodontal Res. In press https://doi.org/10.1111/jre.12649
3. Janjić K, Agis H. (2019) Chronodentistry: the role & potential of molecular clocks in oral medicine. BMC Oral Health. 19(1):32. https://doi.org/10.1186/s12903-019-0720-x
4. Müller AS, Gashi M, Janjić K, Edelmayer M, Moritz A, Agis H. (2019) The impact of clay-based hypoxia mimetic hydrogel on human fibroblasts of the periodontal soft tissue. J Biomater Appl. 2019 885328218821042 In press. https://doi.org/10.1177/0885328218821042
5. Kurzmann C, Verheyen J, Coto M, Kumar RV, Divitini G, Shokoohi-Tabrizi HA, Verheyen P, De Moor RJG, Moritz A, Agis H. (2019) In vitro evaluation of experimental light activated gels for tooth bleaching. Photochem Photobiol Sci. in press. https://doi.org/10.1039/c8pp00223a
6. Samiei M, Janjić K, Cvikl B, Moritz A, Agis H. (2019) The role of sclerostin and dickkopf-1 in oral tissues – A review from the perspective of the dental disciplines. F1000Research. 8:128
7. Janjić K, Bauer P, Edelmayer M, Cvikl B, Schädl B, Moritz A, Agis H. (2018) Angiogenin production in response to hypoxia and l-mimosine in periodontal fibroblasts. J Periodontol. In press https://doi.org/10.1002/JPER.18-0172
8. Oberoi G, Janjić K, Müller AS, Schädl B, Andrukhov O, Moritz A, Agis H, (2018) Contraction Dynamics of Rod Microtissues of Gingiva-derived and Periodontal Ligament-derived Cells. Journal: Frontiers in Physiology. 9:1683 https://doi.org/10.3389/fphys.2018.01683
9. Laky M, Volmer M, Arslan M, Agis H, Moritz A, Cvikl B. (2018) Efficacy and Safety of Photon Induced Photoacoustic Streaming for Removal of Calcium Hydroxide in Endodontic Treatment. Biomed Res Int. 2018:2845705. https://doi.org/10.1155/2018/2845705
10. Oberoi G, Nitsch S, Edelmayer M, Janjić K, Müller AS, Agis H. (2018) 3D printing- Encompassing the facets of dentistry. Frontiers in Bioengineering and Biotechnology. 6:172 https://doi.org/10.3389/fbioe.2018.00172
11. Müller AS, Janjić K, Oberoi G, Pensch M, Kurzmann C, Moritz A, and Agis H. (2018) Desferrioxamine but not dimethyloxalylglycine, L-mimosine or cobalt dichloride can interfere with the MTT assay. 2018:5872865. https://doi.org/10.1155/2018/5872865
12. Al-Habbal D, Janjić K, Edelmayer M, Moritz A, Agis H. (2019) Collagen barrier membranes do not adsorb hypoxia mimetic activity-Activity of gingival fibroblasts cultured directly on collagen barrier membranes loaded with hypoxia mimetic agents. J Biomed Mater Res B Appl Biomater. 106(2):874-879. https://doi.org/10.1002/jbm.b.33893
13. Janjić K, Kurzmann C, Moritz A, Agis H. (2018) Core circadian clock gene expression in human dental pulp-derived cells in response to L-mimosine, hypoxia and echinomycin. Eur J Oral Sci. 126(4):263-271. https://doi.org/10.1111/eos.12535
14. Müller AS, Artner M, Janjić K, Edelmayer M, Kurzmann C, Moritz A, Agis H. (2018) Synthetic Clay-based Hypoxia Mimetic Hydrogel for Pulp Regeneration: The Impact on Cell Activity and Release Kinetics Based on Dental Pulp-derived Cells In Vitro. J Endod. 44(8):1263-1269. https://doi.org/10.1016/j.joen.2018.04.010
15. Janjić K, Alhujazy U, Moritz A, Agis H. (2018) L-mimosine and hypoxia enhance angiopoietin-like 4 production involving hypoxia-inducible factor-1alpha: Insights from monolayer and spheroid cultures of dental pulp-derived cells and tooth slice cultures. Arch Oral Biol. 85:172-177. https://doi.org/10.1016/j.archoralbio.2017.10.011
16. Janjić K, Lilaj B, Moritz A, Agis H. (2018) Formation of spheroids by dental pulp cells in the presence of hypoxia and hypoxia mimetic agents. Int Endod J. Suppl 2:e146-e156. https://doi.org/10.1111/iej.12806
17. Agis H. Hypoxic Preconditioning and Stabilization of HIFs. In: Holnthoner W. (ed) Tissue Engineering and Regeneration: Vascularization for Tissue Engineering and Regenerative Medicine; Angiogenesis Induction. Springer International Publishing 1st. Edition.
18. Kurzmann C, Janjić K, Shokoohi-Tabrizi H, Edelmayer M, Pensch M, Moritz A, Agis H. (2017) Evaluation of Resins for Stereolithographic 3D-Printed Surgical Guides: The Response of L929 Cells and Human Gingival Fibroblasts. Biomed Res Int. 2017;2017:4057612. https://doi.org/10.1155/2017/4057612
19. Janjić K, Edelmayer M, Moritz A, Agis H. L-mimosine and hypoxia can increase angiogenin production in dental pulp-derived cells. (2017) BMC Oral Health. 17(1):87. https://doi.org/10.1186/s12903-017-0373-6
20. Müller AS, Janjić K, Lilaj B, Edelmayer M, Agis H. Hypoxia-based strategies for regenerative dentistry-Views from the different dental fields. Arch Oral Biol. 2017 Sep;81:121-130. https://doi.org/10.1016/j.archoralbio.2017.04.029
21. Edelmayer M, Al-Habbal D, Pensch M, Janjić K, Agis H. Effect of prolyl hydroxylase inhibitor-loaded collagen barrier membranes on osteoclastogenesis and osteoblastogenesis. J Biomater Appl. 2017 May;31(10):1370-1379. https://doi.org/10.1177/0885328217702563
22. Janjić K, Kurzmann C, Moritz A, Agis H. Expression of circadian core clock genes in fibroblasts of human gingiva and periodontal ligament is modulated by L-Mimosine and hypoxia in monolayer and spheroid cultures. Arch Oral Biol. 2017 Jul;79:95-99. https://doi.org/10.1016/j.archoralbio.2017.03.007
23. Mozgan EM, Edelmayer M, Janjić K, Pensch M, Fischer MB, Moritz A, Agis H. Release kinetics and mitogenic capacity of collagen barrier membranes supplemented with secretome of activated platelets - the in vitro response of fibroblasts of the periodontal ligament and the gingiva. BMC Oral Health. 2017 Mar 21;17(1):66. https://doi.org/10.1186/s12903-017-0357-6
24. Knoop C, Edelmayer M, Janjić K, Pensch M, Fischer MB, Gruber R, Agis H. Difference in release kinetics of unwashed and washed platelet-released supernatants from bone substitute materials: the impact of platelet preparation modalities. J Periodontal Res. 2017 Aug;52(4):772-786. https://doi.org/10.1111/jre.12447
25. Cvikl B, Hess SC, Miron RJ, Agis H, Bosshardt D, Attin T, Schmidlin PR, Lussi A. Response of human dental pulp cells to a silver-containing PLGA/TCP-nanofabric as a potential antibacterial regenerative pulp-capping material. BMC Oral Health. 2017 Feb 27;17(1):57. https://doi.org/10.1186/s12903-017-0348-7
26. Wehner C, Janjić K, Agis H. Relevance of the plasminogen system in physiology, pathology, and regeneration of oral tissues - From the perspective of dental specialties. Arch Oral Biol. 2017 Feb;74:136-145. https://doi.org/10.1016/j.archoralbio.2016.09.014
27. Gruber M, Gruber R, Agis H. Transforming growth factor-β1 increases sclerostin in fibroblasts of the periodontal ligament and the gingiva. Matters Archive. 2017 https://doi.org/10.19185/matters.201610000011
28. Janjić K, Cvikl, B, Moritz A, Agis H. Dental pulp regeneration – In vitro und in vivo approaches, Review. l. J. Stomat. Occ. Med. 2016. Https://doi.org/10.1007/s12548-015-0139-1
29. Müller HD, Cvikl B, Janjić K, Nürnberger S, Moritz A, Gruber R, Agis H. Effects of Prolyl Hydroxylase Inhibitor L-mimosine on Dental Pulp in the Presence of Advanced Glycation End Products. J Endod. 2015 Nov;41(11):1852-61. https://doi.org/10.1016/j.joen.2015.08.002
30. Fügl A, Gruber R, Agis H, Lzicar H, Keibl C, Schwarze UY, Dvorak G. Alveolar bone regeneration in response to local application of calcitriol in vitamin D deficient rats. J Clin Periodontol. 2015 Jan;42(1):96-103. https://doi.org/10.1111/jcpe.12342
31. Hamid O, Pensch M, Agis H. Release kinetics of prolyl hydroxylase inhibitors from collagen barrier membranes. J Biomater Appl. 2015 Mar;29(8):1059-67. https://doi.org/10.1177/0885328214556158
32. Vinzenz P, Schröckmair S, Gruber R, Agis H. Bone substitute materials supplemented with prolyl hydroxylase inhibitors decrease osteoclastogenesis in vitro. J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1198-203. https://doi.org/10.1002/jbm.b.33295
33. Kuchler U, Keibl C, Fügl A, Schwarze UY, Tangl S, Agis H, Gruber R. Dimethyloxalylglycine lyophilized onto bone substitutes increase vessel area in rat calvarial defects. Clin Oral Implants Res. 2015 May;26(5):485-91. https://doi.org/10.1111/clr.12474
34. Trimmel K, Cvikl B, Müller HD, Nürnberger S, Gruber R, Moritz A, Agis H. L-mimosine increases the production of vascular endothelial growth factor in human tooth slice organ culture model. Int Endod J. 2015 Mar;48(3):252-60. https://doi.org/10.1111/iej.12307
35. Al Mustafa M, Agis H, Müller HD, Watzek G, Gruber R. In vitro adhesion of fibroblastic cells to titanium alloy discs treated with sodium hydroxide. Clin Oral Implants Res. 2015;26(1):15-9. https://doi.org/10.1111/clr.12294
36. Agis H, Hueber L, Pour Sadeghian N, Pensch M, Gruber R. In vitro release of dimethyloxaloylglycine and l-mimosine from bovine bone mineral. Arch Oral Biol. 2014 Oct;59(10):1024-31. https://doi.org/10.1016/j.archoralbio.2014.05.027
37. Agis H, Collins A, Taut AD, Jin Q, Kruger L, Görlach C, Giannobile WV. Cell population kinetics of collagen scaffolds in ex vivo oral wound repair. PLoS One. 2014 Nov 14;9(11):e112680. https://doi.org/10.1371/journal.pone.0112680
38. Wehner C, Gruber R, Agis H. L-mimosine and dimethyloxaloylglycine decrease plasminogen activation in periodontal fibroblasts. J Periodontol. 2014 Apr;85(4):627-35. https://doi.org/10.1902/jop.2013.120703
39. Hof M, Pommer B, Strbac GD, Vasak C, Agis H, Zechner W. Impact of insertion torque and implant neck design on peri-implant bone level: a randomized split-mouth trial. Clin Implant Dent Relat Res. 2014 Oct;16(5):668-74. https://doi.org/10.1111/cid.12042