| County | Location | mi | km | Destinations | Notes |
|---|---|---|---|---|---|
| Santa Clara | Abel Santamaría Airport | 0 | 0.0 |  Abel Santamaría Airport | Road starts at roundabout |
| 1.000 mi = 1.609 km; 1.000 km = 0.621 mi | |||||
| Municipality | Location | ↓km↓ | Destination | Notes |
|---|---|---|---|---|
| Santa Clara | Abel Santamaria Airport | 0 | Abel Santamaría Airport
|
Road starts at roundabout |
| Santa Clara | Frank País | 3 |  4–311 – Encrucijada
|
No official exit going east on the airport road, although it is common for people to go on the grass in the median. |
| Santa Clara | 15 |  4–321 – Camajuaní, Santa Clara
|
||
| Camajuaní | ? | ? |  4–401 – Camajuani, José María Pérez (planned)
|
|
| Remedios | Nearby Bartolome | ? |  4–461 – Remedios, Zulueta (planned)
|
|
| Remedios | 47 | Carretera a Rojas – Rojas, Remedios (under construction) | 
| |
| Caibarién | 53 | Circuito Norte – Caibarién, Dolores | ||
| Caibarién | Las Brujas Airport | 91 | Las Brujas Airport
|
|
| Caibarién | Cayo Santa María Wildlife Refuge | 106 | Unnamed road – Punta Amanecer | Road to Cayo Santamaria ends at a dirt road |
| Municipality | Location | ↓km↓ | Destination | Notes |
|---|---|---|---|---|
| Ranchuelo | Esperanza | 0 |  Carretera Central
|
|
| Ranchuelo | 9 |  Autopista A1 – Santa Clara, La Habana
|
||
| Ranchuelo | 16 | Road to Ifraín Alfonso – Ifraín Alfonso | unpaved | |
| Cruces | Marta Abreu | 22 |  4–92 – Lajas
|
|
| Cruces | Cruces | 26 | Cruces–Potrerillo Road – Potrerillo, Cumanayagua | |
| Cruces | 26 |  4-182 – Calle Central Ramón Balboa
|
||
| Cruces | 32 | Road of Camarones | ||
| Palmira | Palmira | 42 |  4–172 – Caunao
|
|
| Palmira | Palmira | 43 | Road to Ciego Montero – Arriete-Ciego Montero | |
| Cienfuegos | 50 | Substation Road | ||
| Cienfuegos | Cienfuegos | 52 | Calle 37 | |
| Cienfuegos | Cienfuegos | 53 | Circuito Sur (right/left) Port Road (straight) | Roundabout at the end of the highway |
| Municipality | Location | ↓km↓ | Destination |
|---|---|---|---|
| Nuevitas | Nuevitas | 0 | Calle Albaiza/Calle Agramonte |
| Nuevitas | Nuevitas | 1.4 | Avenida Circunvalación |
| Nuevitas | 10.5 | Circuito Norte | |
| Minas | Entronque de Lugerno | 25 |  5–541 (north)/Road to Playa Santa Lucia (south) – Lugareño, Playa Santa Lucia
|
| Minas | 39.3 | Calle Camilo Cienfuegos – Minas | |
| Minas | Minas | 42.7 |  5–521 Calle Cisneros – Minas
|
| Camagüey | Camagüey | 66 |  5–461 – Paso de Vilató, Sierra de Cubitas
|
| Camagüey | Camagüey | 66.2 | Ignacio Agramonte International Airport–International Terminal
|
| Camagüey | Camagüey | 67.1 | Ignacio Agramonte International Airport–National Terminal
|
| Camagüey | Camagüey | 71.3 | Circunvalación Norte (north/south) Avenida Dr. Carlos Juan Finlay (straight) |