USS Serpens may refer to the following ships of the United States Navy:
- USS Serpens (AK-97), a United States Coast Guard-manned Crater-class cargo ship in World War II.
- USS Serpens (AK-266), an Alchiba-class cargo ship that was on loan to South Korea for the duration of its Navy career (1951–1960).
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.