Two ships of the United States Navy have borne the name USS Puffer, named in honor of the pufferfish, which inflates its body with air.
- USS Puffer (SS-268) was a Gato-class submarine, commissioned in 1943 and struck in 1960.
- USS Puffer (SSN-652) was a Sturgeon-class submarine, commissioned in 1969 and struck in 1996.
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.