USS Mississinewa refers to two ships for the US Navy, both named for the Mississinewa River in eastern Indiana:
- USS Mississinewa (AO-59), a Cimarron-class fleet oiler, was launched 28 March 1944 and sunk 20 November 1944
- USS Mississinewa (AO-144), a Neosho-class fleet oiler, was in service from 1955 to 1991
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.