USP51

Ubiquitin carboxyl-terminal hydrolase 51 is an enzyme that in humans is encoded by the USP51 gene.

USP51
Identifiers
Aliases	USP51, ubiquitin specific peptidase 51
External IDs	MGI: 3588217; HomoloGene: 71495; GeneCards: USP51; OMA:USP51 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.21 Start 55,484,616 bp End 55,489,848 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F3 Start 151,789,465 bp End 151,792,412 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis caput epididymis gonad bronchial epithelial cell retinal pigment epithelium tail of epididymis testicle endothelial cell buccal mucosa cell mucosa of paranasal sinus Top expressed in yolk sac secondary oocyte morula zygote embryo primary oocyte embryo epiblast placenta ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function thiol-dependent deubiquitinase zinc ion binding peptidase activity cysteine-type peptidase activity hydrolase activity metal ion binding chromatin binding histone binding Cellular component chromosome Biological process protein deubiquitination ubiquitin-dependent protein catabolic process proteolysis histone deubiquitination regulation of response to DNA damage stimulus regulation of cell cycle process regulation of double-strand break repair via homologous recombination regulation of double-strand break repair via nonhomologous end joining DNA repair cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 158880 635253 Ensembl ENSG00000247746 ENSMUSG00000067215 UniProt Q70EK9 B1AY15 RefSeq (mRNA) NM_201286 NM_001137547 RefSeq (protein) NP_958443 NP_001131019 Location (UCSC) Chr X: 55.48 – 55.49 Mb Chr X: 151.79 – 151.79 Mb PubMed search
Wikidata
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Further reading

• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Puente XS, López-Otín C (2004). "A genomic analysis of rat proteases and protease inhibitors". Genome Res. 14 (4): 609–22. doi:10.1101/gr.1946304. PMC 383305. PMID 15060002.
• Xie H, Diber A, Pollock S, et al. (2004). "Bridging expressed sequence alignments through targeted cDNA sequencing". Genomics. 83 (4): 572–6. doi:10.1016/j.ygeno.2003.07.003. PMID 15028280.
• Quesada V, Díaz-Perales A, Gutiérrez-Fernández A, et al. (2004). "Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases". Biochem. Biophys. Res. Commun. 314 (1): 54–62. doi:10.1016/j.bbrc.2003.12.050. PMID 14715245.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.