USCGC Seneca may refer to one of the following United States Coast Guard cutters:
- USCGC Seneca (1908), launched 1908; decommissioned 1936; scrapped 1950
- USCGC Seneca (WMEC-906), launched 1984, commissioned 1987; in active service as of 2008
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.