USCGC Mackinac has been the name of more than one United States Revenue Cutter Service and United States Coast Guard ship, and may refer to:

  • USRC Mackinac (1903), a patrol boat which served in the Revenue Cutter Service from 1903 to 1915 and in the Coast Guard (as USCGC Mackinac) from 1915 to 1917 and from 1919 to 1939
  • USCGC Mackinac (WAVP-371), later WHEC-371, a cutter in commission from 1949 to 1967

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