UGT1A

UDP glucuronosyltransferase 1 family, polypeptide A cluster (UGT1A) is a human gene locus which includes several UDP glucuronosyltransferases.

UGT1A
Identifiers
Aliases	UGT1A, GNT1, UGT, UGT1, UGT1A@, UDP glucuronosyltransferase family 1 member A complex locus
External IDs	GeneCards: UGT1A; OMA:UGT1A - orthologs
Orthologs Species Human Mouse Entrez 7361 n/a Ensembl n/a n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

The UGT1A locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.

Further reading

• Mackenzie PI, Owens IS, Burchell B, et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054.
• Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
• King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. doi:10.2174/1389200003339171. PMID 11465080.
• Ritter JK, Chen F, Sheen YY, et al. (1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. doi:10.1016/S0021-9258(19)50724-4. PMID 1339448.
• Gong QH, Cho JW, Huang T, et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. doi:10.1097/00008571-200106000-00011. PMID 11434514.
• Kaplan M, Hammerman C, Rubaltelli FF, et al. (2002). "Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism". Hepatology. 35 (4): 905–11. doi:10.1053/jhep.2002.32526. hdl:11577/2431311. PMID 11915038. S2CID 10749512.
• Peters WH, te Morsche RH, Roelofs HM (2003). "Combined polymorphisms in UDP-glucuronosyltransferases 1A1 and 1A6: implications for patients with Gilbert's syndrome". J. Hepatol. 38 (1): 3–8. doi:10.1016/S0168-8278(02)00306-9. PMID 12480553.
• Zhang T, Haws P, Wu Q (2004). "Multiple Variable First Exons: A Mechanism for Cell- and Tissue-Specific Gene Regulation". Genome Res. 14 (1): 79–89. doi:10.1101/gr.1225204. PMC 314283. PMID 14672974.
• Giuliani L, Ciotti M, Stoppacciaro A, et al. (2005). "UDP-glucuronosyltransferases 1A expression in human urinary bladder and colon cancer by immunohistochemistry". Oncol. Rep. 13 (2): 185–91. doi:10.3892/or.13.2.185 (inactive 1 November 2024). PMID 15643497.{{cite journal}}: CS1 maint: DOI inactive as of November 2024 (link)
• Mercke Odeberg J, Andrade J, Holmberg K, et al. (2007). "UGT1A polymorphisms in a Swedish cohort and a human diversity panel, and the relation to bilirubin plasma levels in males and females". Eur. J. Clin. Pharmacol. 62 (10): 829–37. doi:10.1007/s00228-006-0166-3. PMID 16909274. S2CID 30425233.