U.S. Route 281 Alternate may refer to:
- U.S. Route 281 Alternate (Texas), an alternate route of U.S. Route 281 in South Texas
- U.S. Route 281 Alternate (Great Bend, Kansas), a former alternate route of U.S. Route 281 in Great Bend, Kansas
This disambiguation page lists articles about roads and streets with the same name.
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