Tolloid-like protein 1 is a protein that in humans is encoded by the TLL1 gene.[5][6]

TLL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTLL1, ASD6, TLL, tolloid like 1
External IDsOMIM: 606742; MGI: 106923; HomoloGene: 49202; GeneCards: TLL1; OMA:TLL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001204760
NM_012464

NM_009390

RefSeq (protein)

NP_001191689
NP_036596

NP_033416

Location (UCSC)Chr 4: 165.87 – 166.1 MbChr 8: 64.47 – 64.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. A similar protein in mice is required during heart development and specifically processes procollagen C-propeptides and chordin at similar cleavage sites.[6]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000038295Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053626Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Scott IC, Clark TG, Takahara K, Hoffman GG, Eddy RL, Haley LL, Shows TB, Greenspan DS (Oct 1999). "Assignment of TLL1 and TLL2, which encode human BMP-1/Tolloid-related metalloproteases, to chromosomes 4q32→q33 and 10q23→q24 and assignment of murine Tll2 to chromosome 19". Cytogenet Cell Genet. 86 (1): 64–65. doi:10.1159/000015412. PMID 10516436. S2CID 42081614.
  6. ^ a b "Entrez Gene: TLL1 tolloid-like 1".

Further reading

edit