Thomas Clayton (1777–1854) was an American lawyer and politician.
Thomas Clayton may also refer to:
- Thomas Clayton the Elder (1575-1647), physician and Regious Profess of Anatomy, Oxford
- Thomas Clayton (physician) (c. 1612–1693), MP for Oxford University
- Thomas Clayton (composer) (1673–1725), English musician and opera composer
- Thomas Clayton (American football) (born 1984), American football running back
- Tom Clayton (jockey) (1882–1909), Australian jockey
- Tom Clayton (footballer) (born 2000), English footballer
- Thomas J. Clayton (1826–1900), President Judge of the Thirty-Second Judicial District of Pennsylvania
See also
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