Template:Side effects of combined androgen blockade with nilutamide and surgical castration

Side effects of combined androgen blockade with nilutamide and surgical castration
Class Side effect Nilutamide 150 mg/day +
orchiectomy (n = 225) (%)a,b
Placebo + orchi-
ectomy
(n = 232) (%)a,b
Cardiovascular system Hypertension 5.3 2.6
Digestive system Nausea 9.8 6.0
Constipation 7.1 3.9
Endocrine system Hot flashes 28.4 22.4
Metabolic and nutritional system Increased aspartate transaminase 8.0 3.9
Increased alanine transaminase 7.6 4.3
Nervous system Dizziness 7.1 3.4
Respiratory system Dyspnea 6.2 7.3
Special senses Impaired adaptation to darkness 12.9 1.3
Abnormal vision 6.7 1.7
Urogenital system Urinary tract infection 8.0 9.1
Overall 86 81
Footnotes: a = Phase III studies of combined androgen blockade (nilutamide + orchiectomy) in men with advanced prostate cancer. b = Incidence ≥5% regardless of causality. Sources: [1]