Beta-2 adrenergic receptor

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Inverse agonists "N/A"

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Beta-2 adrenergic receptor
Transduction mechanismsPrimary: Gs
Secondary: Gi/o
Primary endogenous agonistsepinephrine, norepinephrine
Agonistsisoprenaline, salbutamol, salmeterol, etc.
Antagonistscarvedilol, propranolol, labetalol, etc.
Inverse agonistsN/A
Positive allosteric modulatorsZn2+ (low concentrations)
Negative allosteric modulatorsZn2+ (high concentrations)
External resources
IUPHAR/BPS29
DrugBankP07550
HMDBHMDBP01634

Inverse agonists undefined

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Beta-2 adrenergic receptor
Transduction mechanismsPrimary: Gs
Secondary: Gi/o
Primary endogenous agonistsepinephrine, norepinephrine
Agonistsisoprenaline, salbutamol, salmeterol, etc.
Antagonistscarvedilol, propranolol, labetalol, etc.
Positive allosteric modulatorsZn2+ (low concentrations)
Negative allosteric modulatorsZn2+ (high concentrations)
External resources
IUPHAR/BPS29
DrugBankP07550
HMDBHMDBP01634

Inverse agonists parameter missing

edit
Beta-2 adrenergic receptor
Transduction mechanismsPrimary: Gs
Secondary: Gi/o
Primary endogenous agonistsepinephrine, norepinephrine
Agonistsisoprenaline, salbutamol, salmeterol, etc.
Antagonistscarvedilol, propranolol, labetalol, etc.
Positive allosteric modulatorsZn2+ (low concentrations)
Negative allosteric modulatorsZn2+ (high concentrations)
External resources
IUPHAR/BPS29
DrugBankP07550
HMDBHMDBP01634

TAAR1

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Antagonists parameter "None characterized", inverse agonists listed

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Trace amine-associated receptor 1
Transduction mechanismsGs, Gq, GIRKs, β-arrestin 2
Primary endogenous agoniststyramine, β-phenylethylamine, octopamine, dopamine
AgonistsEndogenous: trace amines
Exogenous: RO5166017, amphetamine, methamphetamine, others
Neutral antagonistsNone characterized
Inverse agonistsEPPTB
Positive allosteric modulatorsN/A
Negative allosteric modulatorsN/A
External resources
IUPHAR/BPS364
DrugBankQ96RJ0
HMDBHMDBP10805

Antagonists parameter "N/A"

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Trace amine-associated receptor 1
Transduction mechanismsGs, Gq, GIRKs, β-arrestin 2
Primary endogenous agoniststyramine, β-phenylethylamine, octopamine, dopamine
AgonistsEndogenous: trace amines
Exogenous: RO5166017, amphetamine, methamphetamine, others
Neutral antagonistsN/A
Inverse agonistsEPPTB
Positive allosteric modulatorsN/A
Negative allosteric modulatorsN/A
External resources
IUPHAR/BPS364
DrugBankQ96RJ0
HMDBHMDBP10805

Inverse agonists parameter undefined

edit
Trace amine-associated receptor 1
Transduction mechanismsGs, Gq, GIRKs, β-arrestin 2
Primary endogenous agoniststyramine, β-phenylethylamine, octopamine, dopamine
AgonistsEndogenous: trace amines
Exogenous: RO5166017, amphetamine, methamphetamine, others
AntagonistsNone characterized
Positive allosteric modulatorsN/A
Negative allosteric modulatorsN/A
External resources
IUPHAR/BPS364
DrugBankQ96RJ0
HMDBHMDBP10805