Talk:SOX1

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Latest comment: 10 years ago2 comments2 people in discussion

I would recommend some additional information on the SOX1 gene function and more specifics on the regulation of it in relation to other SOX genes mentioned. One source that has additional information is from an article from Pubmed. This article reviews the Role of SoxB1 transcription factors in development. It discusses the SoxB protein family which includes Sox1, Sox2, and Sox3. They all share 90% of the amino acid structure to influence changes in developmental. Here is the complete reference, Miyagi, S. "Role of SoxB1 Transcription Factors in Development." National Center for Biotechnology Information. U.S. National Library of Medicine, 5 July 2009. Web. 06 Oct. 2013. A more recent article is referenced here, Uchikawa, M. "B1 and B2 Sox Gene Expression during Neural Plate Development in Chicken and Mouse Embryos: Universal versus Species-dependent Features." National Center for Biotechnology Information. U.S. National Library of Medicine, 18 July 2011. Web. 06 Oct. 2013. I would also recommend a photo to add to the information. A chart or some sort of illustration that would better organize the information would be a great additional to this! Ran21 (talk) 00:38, 7 October 2013 (UTC)Reply

I recommend discussing how the modification or the regulation of SOX1 can correlate to clinical outcome of certain diseases. For example, there exist high rates of methylation of SOX1 in cases of cervical adenocarcinoma (reference: Chang, Cheng-Chang, et al. "High Methylation Rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 Genes in Cervical Adenocarcinoma." International journal of gynecological cancer: official journal of the International Gynecological Cancer Society (2014))and how the downregulation of SOX1 can promote drug resistance for lung cancer. Additionally, I believe that the emerging and increasingly possible utility value of this transcription factor should also be referred to. For example, it has been shown that SOX1 activation can trigger the production of highly purified stem cells. Here is the reference: Feng, Nianhua, et al. "Generation of Highly Purified Neural Stem Cells from Human Adipose-Derived Mesenchymal Stem Cells by Sox1 Activation." Stem cells and development (2013).

— Preceding unsigned comment added by Pparik10 (talk • contribs) 00:53, 3 February 2014 (UTC)Reply

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