Talk:Pyruvate dehydrogenase

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Pyruvate dehydrogenase and pyruvate decarboxylase are two different, totally unrelated enzymes, and therefore the subjects should not be merged. —Preceding unsigned comment added by Lulubou (talk • contribs) 22:07, 5 March 2009 (UTC)

Could an imbalance of this enzyme cause an unexplainable critical lactic acid ? I’m not a doc or scientist, I’m just a mom. My 26 yr old daughter has been hospitalized for a week due to micro plasma pneumonia. Her lactic acid went to 5.7 then it has went up and down between 5.7 and 2.5 ( never getting out of critical range) in coorelation with bolus fluids. Liver enzymes spiked to 300. Today her labs are starting to stabilize BUT the lactic acid has went back up to 3.9. The docs have tested for everything they can think of. Every blood culture possible and still no answers. All Ct scans have been negative. Echo. Normal. I’m grasping for straws as to what could be the cause. She doesn’t smoke vape, she is very fit and healthy. I’d appreciate any suggestions that I can present to the doctor. Thanks! 2603:6010:3506:AAAD:BD8E:8EA1:5A34:5CEE (talk) 16:59, 20 July 2024 (UTC)

The two different totally unrelated enzymes are / are not physically in a complex of some kind? Richard8081 (talk) 03:51, 21 July 2012 (UTC)

There are many different kinds of pyruvate dehydrogenase than the E1 of the pyruvate dehydrogenase complex. The article need to talk about them as well. Some of this info might be better in pyruvate dehydrogenase complex. Qchristensen (talk) 08:09, 10 April 2014 (UTC)

Assessment comment

The comment(s) below were originally left at Talk:Pyruvate dehydrogenase/Comments, and are posted here for posterity. Following several discussions in past years, these subpages are now deprecated. The comments may be irrelevant or outdated; if so, please feel free to remove this section.

I'd like to suggest that the pyruvate dehydrogenase (E.C. 1.2.4.1) article should not be merged with the pyruvate decarboxylase (E.C. 4.1.1.1) article as the two refer to different enzymes and reactions. Indeed, it can be seen from the EC #'s above that pyruvate dehydrogenase is an oxidoreductase wheras pyruvate decarboxylate is a lyase, although they share a common cofactor and substrate. 64.136.179.116 (talk) 18:35, 16 September 2008 (UTC)

Last edited at 18:35, 16 September 2008 (UTC). Substituted at 03:35, 30 April 2016 (UTC)

Research on Myalgic encephalopathi ME/CFS

This is very important for us with this illness, especially since there hasn't been that good research before. Could you incorporate this article? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/ Toove (talk) 04:27, 25 September 2018 (UTC)