Talk:Phosphofructokinase 2

Wiki Education Foundation-supported course assignment

This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Kedrosolan. Peer reviewers: Ssbusse.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 06:35, 17 January 2022 (UTC)

several suggestions/media improvement

I think that this enzyme’s bifunctionality should be more greatly emphasized and explained. I have a couple of specific edits I would like to make in hopes of improving this page. These include:

-adding a 3D ribbon/surface model image that more specifically displays secondary protein structure and active sites to supplement “Structure” section

-images/space filler models that display structural difference between the PFK-2/FBPase2 and each enzyme state appears depending on which domain is phosphorylated (perhaps using zoomed-in, stick model to show when Ser-32 is phosphorylated)

-Clarify the “Reaction mechanism” section by creating an accompanying image - I think that readers could benefit by having a picture of the reaction for reference when reading the different steps

-Add cycle diagram to show how enzyme regulates glycolysis and gluconeogenesis so that readers understand switch from fructose-6-phosphate to fructose-2,6-biphosphate; hopefully this would visually supplement the “Regulation” section

-Potentially adding how a clearer difference between muscle/liver action, and within liver, fed/fasting state? Or would that be too specific to include in this article?

Thoughts? Thanks!

Kedrosolan (talk) 20:14, 15 February 2018 (UTC)

merge proposal

It seems the name of this gene is outdated, I propose a merge to: https://en.wikipedia.org/wiki/PFKFB1 — Preceding unsigned comment added by Ethylfox (talk • contribs) 15:40, 13 July 2015 (UTC)

nomenclature and importance

This enzyme is being recognized as a key regulator of carbohydrate metabolism. It is also being increasingly referred to as the "bifunctional enzyme". The latter, though it seems disturbingly nonspecific, is certainly easier than the messy combination of both enzyme names. Is anyone else in favor of renaming the principal article bifunctional enzyme, and changing this phosphofructokinase 2 to a redirect-- i.e., the opposite of current situation? alteripse (talk) 11:45, 11 April 2009 (UTC)